Understanding the multiple functions of Gr-1 super(+) cell subpopulations during microbial infection
The murine cell surface determinant Gr-1 is expressed at high level on neutrophils. Depletion of polymorphonuclear leukocytes with anti-Gr-1 super(+) monoclonal antibody results in increased susceptibility and dysregulated immunity to many microbial pathogens, a finding widely interpreted to indicat...
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Veröffentlicht in: | Immunologic research 2008-01, Vol.40 (1), p.35-48 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The murine cell surface determinant Gr-1 is expressed at high level on neutrophils. Depletion of polymorphonuclear leukocytes with anti-Gr-1 super(+) monoclonal antibody results in increased susceptibility and dysregulated immunity to many microbial pathogens, a finding widely interpreted to indicate the importance of neutrophils during infection. Yet, in recent years it has become clear that additional cell types express the Gr-1 determinant, including dendritic cell and monocyte subpopulations. In this review, we evaluate current knowledge on the functional aspects of Gr-1 super(+) cell populations. We focus on infection with the opportunistic protozoan Toxoplasma gondii, a case where host survival depends on an intact Gr-1 super(+) cell population. |
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ISSN: | 0257-277X |
DOI: | 10.1007/s12026-007-0061-8 |