Nucleotide Sequence Diversity of the bexA Gene in Serotypeable Haemophilus influenzae Strains Recovered from Invasive Disease Patients in Canada

The bexA genes of 36 Haemophilus influenzae isolates were sequenced to reveal their nucleotide sequence diversity, which divided them into two groups, similar to clonal divisions I and II. This sequence diversity may lead to false-negative PCR results for H. influenzae infections if bexA is the chos...

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Veröffentlicht in:	Journal of Clinical Microbiology 2007-06, Vol.45 (6), p.1996-1999
Hauptverfasser:	Zhou, Jianwei, Law, Dennis K.S, Sill, Michelle L, Tsang, Raymond S.W
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP-Binding Cassette Transporters - genetics Bacterial Proteins - genetics Bacteriology Base Sequence Biological and medical sciences Canada False Negative Reactions Fundamental and applied biological sciences. Psychology Genetic Variation Haemophilus Infections - microbiology Haemophilus influenzae Haemophilus influenzae - classification Haemophilus influenzae - genetics Haemophilus influenzae - isolation & purification Humans Infectious diseases Medical sciences Microbiology Miscellaneous Molecular Sequence Data Phylogeny Polymerase Chain Reaction - methods Sequence Analysis, DNA Serotyping
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Zusammenfassung:	The bexA genes of 36 Haemophilus influenzae isolates were sequenced to reveal their nucleotide sequence diversity, which divided them into two groups, similar to clonal divisions I and II. This sequence diversity may lead to false-negative PCR results for H. influenzae infections if bexA is the chosen gene target.
ISSN:	0095-1137 1098-660X 1098-5530
DOI:	10.1128/JCM.00612-07