Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice
Transgenic FVB/N female mice carrying HER-2/neu mammary cancer gene received metformin (1200 mg/liter) with drinking water 5 days a week starting from the age of 2 months until natural death. Metformin slightly reduced food consumption, but did not change water consumption and dynamics of weight gai...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2005-06, Vol.139 (6), p.721-723 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Anisimov, V N Egormin, P A Bershtein, L M Zabezhinskii, M A Piskunova, T S Popovich, I G Semenchenko, A V |
| description | Transgenic FVB/N female mice carrying HER-2/neu mammary cancer gene received metformin (1200 mg/liter) with drinking water 5 days a week starting from the age of 2 months until natural death. Metformin slightly reduced food consumption, but did not change water consumption and dynamics of weight gain. Mean life span of mice increased by 8% (p |
| doi_str_mv | 10.1007/s10517-005-0389-9 |
| format | Article |
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Metformin slightly reduced food consumption, but did not change water consumption and dynamics of weight gain. Mean life span of mice increased by 8% (p<0.05), in 10% long-living mice it was prolonged by 13.1%, and the maximum life span was prolonged by 1 month under the effect of metformin in comparison with the control. The rate of populational aging decreased by 2.26 times. The total incidence of mammary adenocarcinoma and their multiplicity did not change under the effect of metformin, while the latency of tumor development increased and the mean diameter of tumors decreased. Hence, we first demonstrated a geroprotective effect of metformin and its suppressive effect towards the development of mammary tumors.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-005-0389-9</identifier><identifier>PMID: 16224592</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Adenocarcinoma - pathology ; Adenocarcinoma - prevention & control ; Animals ; Female ; Homozygote ; Hypoglycemic Agents - pharmacology ; Longevity - drug effects ; Mammary Neoplasms, Animal - chemically induced ; Mammary Neoplasms, Experimental - pathology ; Mammary Neoplasms, Experimental - prevention & control ; Metformin - pharmacology ; Mice ; Mice, Transgenic ; Receptor, ErbB-2 - genetics ; Survival Analysis ; Time Factors</subject><ispartof>Bulletin of experimental biology and medicine, 2005-06, Vol.139 (6), p.721-723</ispartof><rights>Springer Science+Business Media, Inc. 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-7ae04db9bf037810e20b6fbb6f59843328d4f280e9d148425ccec9d540a73bc23</citedby><cites>FETCH-LOGICAL-c357t-7ae04db9bf037810e20b6fbb6f59843328d4f280e9d148425ccec9d540a73bc23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16224592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anisimov, V N</creatorcontrib><creatorcontrib>Egormin, P A</creatorcontrib><creatorcontrib>Bershtein, L M</creatorcontrib><creatorcontrib>Zabezhinskii, M A</creatorcontrib><creatorcontrib>Piskunova, T S</creatorcontrib><creatorcontrib>Popovich, I G</creatorcontrib><creatorcontrib>Semenchenko, A V</creatorcontrib><title>Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><description>Transgenic FVB/N female mice carrying HER-2/neu mammary cancer gene received metformin (1200 mg/liter) with drinking water 5 days a week starting from the age of 2 months until natural death. Metformin slightly reduced food consumption, but did not change water consumption and dynamics of weight gain. Mean life span of mice increased by 8% (p<0.05), in 10% long-living mice it was prolonged by 13.1%, and the maximum life span was prolonged by 1 month under the effect of metformin in comparison with the control. The rate of populational aging decreased by 2.26 times. The total incidence of mammary adenocarcinoma and their multiplicity did not change under the effect of metformin, while the latency of tumor development increased and the mean diameter of tumors decreased. Hence, we first demonstrated a geroprotective effect of metformin and its suppressive effect towards the development of mammary tumors.</description><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - prevention & control</subject><subject>Animals</subject><subject>Female</subject><subject>Homozygote</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Longevity - drug effects</subject><subject>Mammary Neoplasms, Animal - chemically induced</subject><subject>Mammary Neoplasms, Experimental - pathology</subject><subject>Mammary Neoplasms, Experimental - prevention & control</subject><subject>Metformin - pharmacology</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Receptor, ErbB-2 - genetics</subject><subject>Survival Analysis</subject><subject>Time Factors</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkM1KAzEURoMotlYfwI0EF-5i8zedZCmlWqEiiG7chEzmTpnSZGoyI_j2prQguAgh4Xxfcg9C14zeM0rLaWK0YCWhtCBUKE30CRqzohREcc5O0ZhmiEil1AhdpLTZH-mMnaMRm3EuC83H6PMF-qaLvg24BgdbiLaHhO26DWtsQ51vv2Hb7TyEHncN9tZ7G39wP_guJpxjy8Ub4dMAA-6jDWkNoXXYtw4u0VljtwmujvsEfTwu3udLsnp9ep4_rIgTRdmT0gKVdaWrhopSMQqcVrOmyqvQSgrBVS0brijomkkleeEcOF0XktpSVI6LCbo79O5i9zVA6o1vUx5lawN0QzIs1-QYy-DtP3DTDTHkvxnOhNQsP58hdoBc7FKK0JhdbPcjG0bN3ro5WDfZutlbNzpnbo7FQ-Wh_kscNYtfiG18iQ</recordid><startdate>200506</startdate><enddate>200506</enddate><creator>Anisimov, V N</creator><creator>Egormin, P A</creator><creator>Bershtein, L M</creator><creator>Zabezhinskii, M A</creator><creator>Piskunova, T S</creator><creator>Popovich, I G</creator><creator>Semenchenko, A V</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>200506</creationdate><title>Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice</title><author>Anisimov, V N ; 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| ispartof | Bulletin of experimental biology and medicine, 2005-06, Vol.139 (6), p.721-723 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adenocarcinoma - pathology Adenocarcinoma - prevention & control Animals Female Homozygote Hypoglycemic Agents - pharmacology Longevity - drug effects Mammary Neoplasms, Animal - chemically induced Mammary Neoplasms, Experimental - pathology Mammary Neoplasms, Experimental - prevention & control Metformin - pharmacology Mice Mice, Transgenic Receptor, ErbB-2 - genetics Survival Analysis Time Factors |
| title | Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice |
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