Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice

Transgenic FVB/N female mice carrying HER-2/neu mammary cancer gene received metformin (1200 mg/liter) with drinking water 5 days a week starting from the age of 2 months until natural death. Metformin slightly reduced food consumption, but did not change water consumption and dynamics of weight gai...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2005-06, Vol.139 (6), p.721-723
Hauptverfasser:	Anisimov, V N, Egormin, P A, Bershtein, L M, Zabezhinskii, M A, Piskunova, T S, Popovich, I G, Semenchenko, A V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology Adenocarcinoma - prevention & control Animals Female Homozygote Hypoglycemic Agents - pharmacology Longevity - drug effects Mammary Neoplasms, Animal - chemically induced Mammary Neoplasms, Experimental - pathology Mammary Neoplasms, Experimental - prevention & control Metformin - pharmacology Mice Mice, Transgenic Receptor, ErbB-2 - genetics Survival Analysis Time Factors
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Zusammenfassung:	Transgenic FVB/N female mice carrying HER-2/neu mammary cancer gene received metformin (1200 mg/liter) with drinking water 5 days a week starting from the age of 2 months until natural death. Metformin slightly reduced food consumption, but did not change water consumption and dynamics of weight gain. Mean life span of mice increased by 8% (p
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-005-0389-9