Inhibitory effect of resin composite containing S-PRG filler on Streptococcus mutans glucose metabolism

Resin composites containing surface pre-reacted glass-ionomer (S-PRG) fillers have been reported to inhibit Streptococcus mutans growth on their surfaces, and their inhibitory effects were attributed to BO33− and F− ions. The aim of this study was to evaluate S. mutans acid production through glucose metabolism on resin composite containing S-PRG fillers and assess inhibitory effects of BO33− and F− on S. mutans metabolic activities. The pH change through S. mutans acid production on experimental resin composite was periodically measured after the addition of glucose. Inhibitory effects of BO33− or F− solutions on S. mutans metabolism were evaluated by XTT assays and measurement of the acid production rate. The pH of experimental resin containing S-PRG fillers was significantly higher than that of control resin containing silica fillers (p