Selected health and lifestyle factors, cytosine‐adenine‐guanine status, and phenoconversion in Huntington's disease
ABSTRACT Background: In Huntington's disease, 60% of the variance in onset age is not explained by the huntingtin gene mutation. Huntington's disease onset was earlier in caffeine users. Objective: The objective of this study was to assess the relationship of lifestyle factors with motor p...
Gespeichert in:
Veröffentlicht in: | Movement disorders 2018-03, Vol.33 (3), p.472-478 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | ABSTRACT
Background: In Huntington's disease, 60% of the variance in onset age is not explained by the huntingtin gene mutation. Huntington's disease onset was earlier in caffeine users.
Objective: The objective of this study was to assess the relationship of lifestyle factors with motor phenoconversion among persons at risk for Huntington's disease.
Methods: The associations of motor phenoconversion and exposure to selected lifestyle and health factors were examined using Cox proportional hazards analyses adjusted for age, gender, and repeat length.
Results: Of 247 participants, 36 (14.6%) phenoconverted. Mean follow‐up was 4.2 years. Greater caffeinated soda use was associated with an increased hazard of phenoconversion: moderate use hazard ratio 2.26 (95% confidence interval 0.59‐8.71), high use hazard ratio 4.05 (95% confidence interval 1.18‐13.96).
Conclusions: Huntington's disease onset was earlier among consumers of caffeinated soda, but not other caffeinated beverages. This finding may be spurious or not related to caffeine. © 2018 International Parkinson and Movement Disorder Society |
---|---|
ISSN: | 0885-3185 1531-8257 |
DOI: | 10.1002/mds.27239 |