Selected health and lifestyle factors, cytosine‐adenine‐guanine status, and phenoconversion in Huntington's disease

ABSTRACT Background: In Huntington's disease, 60% of the variance in onset age is not explained by the huntingtin gene mutation. Huntington's disease onset was earlier in caffeine users. Objective: The objective of this study was to assess the relationship of lifestyle factors with motor p...

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Veröffentlicht in:Movement disorders 2018-03, Vol.33 (3), p.472-478
Hauptverfasser: Tanner, Caroline, Marder, Karen, Eberly, Shirley, Biglan, Kevin, Oakes, David, Shoulson, Ira
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Sprache:eng
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Zusammenfassung:ABSTRACT Background: In Huntington's disease, 60% of the variance in onset age is not explained by the huntingtin gene mutation. Huntington's disease onset was earlier in caffeine users. Objective: The objective of this study was to assess the relationship of lifestyle factors with motor phenoconversion among persons at risk for Huntington's disease. Methods: The associations of motor phenoconversion and exposure to selected lifestyle and health factors were examined using Cox proportional hazards analyses adjusted for age, gender, and repeat length. Results: Of 247 participants, 36 (14.6%) phenoconverted. Mean follow‐up was 4.2 years. Greater caffeinated soda use was associated with an increased hazard of phenoconversion: moderate use hazard ratio 2.26 (95% confidence interval 0.59‐8.71), high use hazard ratio 4.05 (95% confidence interval 1.18‐13.96). Conclusions: Huntington's disease onset was earlier among consumers of caffeinated soda, but not other caffeinated beverages. This finding may be spurious or not related to caffeine. © 2018 International Parkinson and Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.27239