Protocol for the Incorporation of γ‑Amino Acids into Peptides: Application to (−)-Shikimic Acid Based 2‑Amino-Methylcyclohexanecarboxylic Acids

Protocol for the Incorporation of γ‑Amino Acids into Peptides: Application to (−)-Shikimic Acid Based 2‑Amino-Methylcyclohexanecarboxylic Acids

The first example of a new protocol for the incorporation of γ-amino acids into peptides is reported. It involved a shikimic acid based stereoselective synthesis polyhydroxylated-2-nitromethylcyclohexanecarboxylic acids, which were directly incorporated into peptides.

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Veröffentlicht in:Journal of organic chemistry 2018-02, Vol.83 (3), p.1543-1550
Hauptverfasser: González, Marcos A, Estévez, Amalia M, Campos, María, Estévez, Juan C, Estévez, Ramón J
Format: Artikel
Sprache:eng
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Zusammenfassung:The first example of a new protocol for the incorporation of γ-amino acids into peptides is reported. It involved a shikimic acid based stereoselective synthesis polyhydroxylated-2-nitromethylcyclohexanecarboxylic acids, which were directly incorporated into peptides.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.7b02671