DKK3 (Dickkopf 3) Alters Atherosclerotic Plaque Phenotype Involving Vascular Progenitor and Fibroblast Differentiation Into Smooth Muscle Cells

OBJECTIVE—DKK3 (dickkopf 3), a 36-kD secreted glycoprotein, has been shown to be involved in the differentiation of partially reprogrammed cells and embryonic stem cells to smooth muscle cells (SMCs), but little is known about its involvement in vascular disease. This study aims to assess the effect...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2018-02, Vol.38 (2), p.425-437
Hauptverfasser:	Karamariti, Eirini, Zhai, Chungang, Yu, Baoqi, Qiao, Lei, Wang, Zhihong, Potter, Claire M.F, Wong, Mei Mei, Simpson, Russell M.L, Zhang, Zhongyi, Wang, Xiaocong, del Barco Barrantes, Ivan, Niehrs, Christof, Kong, Deling, Zhao, Qiang, Zhang, Yun, Hu, Yanhua, Zhang, Cheng, Xu, Qingbo
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 6 - genetics Activating Transcription Factor 6 - metabolism Adaptor Proteins, Signal Transducing Animals Aorta - metabolism Aorta - pathology Aortic Diseases - genetics Aortic Diseases - metabolism Aortic Diseases - pathology Ataxin-1 - metabolism Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology Carotid Arteries - metabolism Carotid Arteries - pathology Carotid Stenosis - genetics Carotid Stenosis - metabolism Carotid Stenosis - pathology Cell Transdifferentiation Cells, Cultured Chemokines Disease Models, Animal Female Fibroblasts - metabolism Fibroblasts - pathology Hemorrhage - genetics Hemorrhage - metabolism Hemorrhage - pathology Hemorrhage - prevention & control Humans Intercellular Signaling Peptides and Proteins - deficiency Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Male Mice, Inbred C57BL Mice, Knockout, ApoE Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Phenotype Plaque, Atherosclerotic Rabbits Stem Cells - metabolism Stem Cells - pathology Transforming Growth Factor beta1 - metabolism Wnt Signaling Pathway
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