Exploiting the apicoplast: apicoplast-targeting drugs and malaria vaccine development

Exploiting the apicoplast: apicoplast-targeting drugs and malaria vaccine development

The apicoplast, a relic plastid found in most Apicomplexan parasites, is a notable drug target. Certain antibiotics elicit a delayed death phenotype by targeting this organelle. Here, we review apicoplast-targeting drugs and their targets, particularly those that cause delayed death, and highlight i...

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Veröffentlicht in:Microbes and infection 2018-10, Vol.20 (9-10), p.477-483
Hauptverfasser: Low, Leanne M., Stanisic, Danielle I., Good, Michael F.
Format: Artikel
Sprache:eng
Schlagworte:
Antimalarial drugs
Apicoplast
Delayed death
Malaria
Vaccines
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Zusammenfassung:The apicoplast, a relic plastid found in most Apicomplexan parasites, is a notable drug target. Certain antibiotics elicit a delayed death phenotype by targeting this organelle. Here, we review apicoplast-targeting drugs and their targets, particularly those that cause delayed death, and highlight its potential uses in malaria vaccine development.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2017.12.005