Development of an Amine-Catalyzed Regioselective Synthesis of Pyrroles
A regioselective synthesis of pyrroles has been devised through the cycloaddition of 1,3-oxazolium-5-olates and enamines. Product regiochemistry is controlled by the enamine substitution pattern. Moreover, an amine-catalyzed variant of this reaction allows aldehydes to be used directly as substrates...
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| Veröffentlicht in: | Organic letters 2018-01, Vol.20 (1), p.201-203 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A regioselective synthesis of pyrroles has been devised through the cycloaddition of 1,3-oxazolium-5-olates and enamines. Product regiochemistry is controlled by the enamine substitution pattern. Moreover, an amine-catalyzed variant of this reaction allows aldehydes to be used directly as substrates for pyrrole synthesis. |
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| ISSN: | 1523-7060 1523-7052 |
| DOI: | 10.1021/acs.orglett.7b03658 |