Is H3K4me1 at enhancers correlative or causative?

Is H3K4me1 at enhancers correlative or causative?

H3K4me1 is enriched at active and primed enhancers. However, whether H3K4me1 controls or simply correlates with enhancer activity and function has remained unclear. Several recent reports, including two in Nature Genetics , provide major mechanistic and functional insights into the role of H3K4me1 a...

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Veröffentlicht in:Nature genetics 2018-01, Vol.50 (1), p.4-5
1. Verfasser: Rada-Iglesias, Alvaro
Format: Artikel
Sprache:eng
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Beschreibung
Zusammenfassung:H3K4me1 is enriched at active and primed enhancers. However, whether H3K4me1 controls or simply correlates with enhancer activity and function has remained unclear. Several recent reports, including two in Nature Genetics , provide major mechanistic and functional insights into the role of H3K4me1 at enhancers.
ISSN:1061-4036
1546-1718
DOI:10.1038/s41588-017-0018-3