Clinical usefulness of prognostic biomarkers in optic neuritis

Background and purpose Different biological and radiological biomarkers predict clinical conversion to multiple sclerosis (MS) after a clinically isolated syndrome (CIS). The aim was to explore their role in predicting the outcome of patients with optic neuritis (ON), a CIS considered to have a beni...

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Veröffentlicht in:European journal of neurology 2018-04, Vol.25 (4), p.614-618
Hauptverfasser: Tejeda‐Velarde, A., Costa‐Frossard, L., Sainz de la Maza, S., Carrasco, Á., Espiño, M., Picón, C., Toboso, I., Walo, P. E., Lourido, D., Muriel, A., Álvarez‐Cermeño, J. C., Villar, L. M.
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Sprache:eng
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Zusammenfassung:Background and purpose Different biological and radiological biomarkers predict clinical conversion to multiple sclerosis (MS) after a clinically isolated syndrome (CIS). The aim was to explore their role in predicting the outcome of patients with optic neuritis (ON), a CIS considered to have a benign prognosis. Methods Sixty‐eight consecutive ON patients were followed prospectively. Magnetic resonance imaging (MRI) and cerebrospinal fluid studies including oligoclonal immunoglobulin G (IgG) bands (OCGBs), lipid‐specific oligoclonal IgM bands (LS‐OCMBs) and neurofilament light chain quantification were performed at disease onset. Conversion to clinically definite MS (CDMS) was monitored. Results The mean time of follow‐up of our series was 46.4 months. Twenty‐five patients (36.7%) developed CDMS during follow‐up. Neurofilament light chain levels did not predict clinical conversion. By contrast, an abnormal MRI increased the risk of CDMS [hazard ratio (HR) 12.5, P = 0.013]. The clearest association was found in patients with more than three T2 lesions. OCGBs also predicted the onset of CDMS (HR 21.3, P = 0.003) and LS‐OCMBs were associated with a shorter time to CDMS (HR = 116.6, P 
ISSN:1351-5101
1468-1331
DOI:10.1111/ene.13553