Arabinofuranose 1,2,5-orthobenzoate as a single precursor of linear α(1 → 5)-linked oligoarabinofuranosides

Selectively protected mono-, di- and trisaccharide thioglycoside building blocks with unprotected primary hydroxy group at the non-reducing end, available in only one step from 3-O-benzoyl β-d-arabinofuranose 1,2,5-orthobenzoate, were used in the synthesis of linear α(1 → 5)-linked oligoarabinofuran...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Carbohydrate research 2018-02, Vol.456, p.35-44
Hauptverfasser: Panova, Maria V., Podvalnyy, Nikita M., Okun, Eugene L., Abronina, Polina I., Chizhov, Alexander O., Kononov, Leonid O.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Selectively protected mono-, di- and trisaccharide thioglycoside building blocks with unprotected primary hydroxy group at the non-reducing end, available in only one step from 3-O-benzoyl β-d-arabinofuranose 1,2,5-orthobenzoate, were used in the synthesis of linear α(1 → 5)-linked oligoarabinofuranosides up to octasaccharide. The obtained oligosaccharides contain 4-(2-chloroethoxy)phenyl (CEP) or 4-(2-azidoethoxy)phenyl (AEP) pre-spacer aglycons that allow preparation of neoglycoconjugates. [Display omitted] •Linear α(1 → 5)-oligoarabinofuranosides up to octasaccharide were synthesized.•All the building blocks used were obtained from arabinofuranose 1,2,5-orthobenzoate.•The obtained oligosaccharides contain 4-(2-chloroethoxy)phenyl pre-spacer aglycon.
ISSN:0008-6215
1873-426X
DOI:10.1016/j.carres.2017.11.002