PXR: A New Player in Atopic Dermatitis

PXR: A New Player in Atopic Dermatitis

Epidemiological evidence suggests that environmental pollutants contribute to atopic dermatitis, but mechanistic details are currently lacking. Elentner et al. show that PXR, a key transcription factor involved in pollutant metabolism, drives features of subclinical atopic dermatitis. These observat...

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Veröffentlicht in:Journal of investigative dermatology 2018-01, Vol.138 (1), p.8-10
Hauptverfasser: Oetjen, Landon K., Trier, Anna M., Kim, Brian S.
Format: Artikel
Sprache:eng
Schlagworte:
Dermatitis, Atopic - immunology
Eczema
Epidermis
Gene Expression Regulation
Humans
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Zusammenfassung:Epidemiological evidence suggests that environmental pollutants contribute to atopic dermatitis, but mechanistic details are currently lacking. Elentner et al. show that PXR, a key transcription factor involved in pollutant metabolism, drives features of subclinical atopic dermatitis. These observations provide new insight into how environmental insults may predispose individuals to atopic dermatitis.
ISSN:0022-202X
1523-1747
1523-1747
DOI:10.1016/j.jid.2017.08.002