Palladium-catalyzed synthesis of fluoreones from bis(2-bromophenyl)methanols

Palladium-catalyzed synthesis of fluoreones from bis(2-bromophenyl)methanols

A palladium-catalyzed synthesis method of fluorenones has been developed. A variety of bis(2-bromophenyl)methanols could undergo the reaction smoothly in the presence of Pd(OAc) , affording a series of fluorenones in moderate to good yields (two steps). Mechanistic studies reveal that the reaction m...

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Veröffentlicht in:Organic & biomolecular chemistry 2018, Vol.16 (2), p.208-212
Hauptverfasser: Gao, Qian, Xu, Senmiao
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols
Chemical synthesis
Oxidation
Palladium
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Zusammenfassung:A palladium-catalyzed synthesis method of fluorenones has been developed. A variety of bis(2-bromophenyl)methanols could undergo the reaction smoothly in the presence of Pd(OAc) , affording a series of fluorenones in moderate to good yields (two steps). Mechanistic studies reveal that the reaction might be triggered by oxidation of alcohol followed by intramolecular reductive coupling.
ISSN:1477-0520
1477-0539
DOI:10.1039/c7ob02895d