Nanoparticles of metal-organic cages designed to encapsulate platinum-based anticancer agents

Nanoparticles of metal-organic cages designed to encapsulate platinum-based anticancer agents

We present a novel design to use metal-organic cages (MOCs) to encapsulate Pt-based anticancer agents for delivery. A fluorescein-conjugated Pt(iv) prodrug of cisplatin is developed for its encapsulation in a cationic MOC via host-guest interactions, which then forms drug-loaded nanoparticles with a...

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Veröffentlicht in:Dalton transactions : an international journal of inorganic chemistry 2018, Vol.47 (3), p.670-674
Hauptverfasser: Yue, Zhizhou, Wang, Han, Bowers, David J, Gao, Min, Stilgenbauer, Morgan, Nielsen, Frederick, Shelley, Jacob T, Zheng, Yao-Rong
Format: Artikel
Sprache:eng
Schlagworte:
Anticancer properties
Cages
Cancer
Encapsulation
Fluorescein
Nanoparticles
Platinum
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Zusammenfassung:We present a novel design to use metal-organic cages (MOCs) to encapsulate Pt-based anticancer agents for delivery. A fluorescein-conjugated Pt(iv) prodrug of cisplatin is developed for its encapsulation in a cationic MOC via host-guest interactions, which then forms drug-loaded nanoparticles with an anionic polymer.
ISSN:1477-9226
1477-9234
DOI:10.1039/c7dt03537c