Time dependent effect of gentamicin on enzymes of carbohydrate metabolism and terminal digestion in rat intestine
Gentamicin (GM) is an aminoglycoside antibiotic commonly used against life threatening gram negative bacterial infections, however, nephrotoxicity remains the major concern for its long term use. Although its effects on kidney are well characterized but there have been no studies regarding its effec...
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| Veröffentlicht in: | Human & experimental toxicology 2007-07, Vol.26 (7), p.587-593 |
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| description | Gentamicin (GM) is an aminoglycoside antibiotic commonly used against life threatening gram negative bacterial infections, however, nephrotoxicity remains the major concern for its long term use. Although its effects on kidney are well characterized but there have been no studies regarding its effects on intestine. We hypothesize that GM causes adaptive coordinated effect on enzymes of carbohydrate metabolism and terminal digestion/ absorption in rat intestine. Rats were administerd a nephrotoxic dose of GM (80 mg /kg body weight) daily for 15 days and a time dependent effect was observed on various enzyme activities. Activities of lactate (LDH), malate (MDH) and isocitrate (ICDH) dehydrogenases, significantly increased and peaked at different time intervals of GM treatment. Whereas LDH activity remained higher, MDH and ICDH activity slowly declined from their peak values. Activities of fructose-1,6-bisphosphatase, glucose-6-phosphatase and glucose-6-phosphate dehydrogenase increased but malic enzyme decreased in a time dependent manner. Activity of alkaline phosphatase and sucrase significantly increased but γ-glutamyl transpeptidase activity decreased. GM administration increased lipid peroxidation, glutathione peroxidase but decreased superoxide dismutase and catalase activities. The results indicate that GM treatment selectively upregulated certain enzymes of carbohydrate metabolism and terminal digestion/absorption and perturbed antioxidant defenses.
Human & Experimental Taxicology, (2007) 26, 587—593. |
| doi_str_mv | 10.1177/09603271079544 |
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Human & Experimental Taxicology, (2007) 26, 587—593.</description><subject>Alkaline Phosphatase - metabolism</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - toxicity</subject><subject>Antibacterial agents</subject><subject>Antibiotics</subject><subject>Antibiotics. Antiinfectious agents. 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Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Side effects</subject><subject>Small intestine</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Time Factors</subject><subject>Toxicology</subject><issn>0960-3271</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc1r3DAQxUVpaLZprz0WUWgvxYlGki3pWEK_IJBLcjayPNoqWPJG8h62f31ldmFpoadBer_3ZqQh5B2wawClbpjpmOAKmDKtlC_IBqRSDTNMvCSbVWxW9ZK8LuWJMdaZFl6RS1BaS9OJDXl-CBHpiDtMI6aFovfoFjp7uq1HG4MLic6JYvp9iFhWwdk8zL8OY7YL0oiLHeYplEhtGumCOYZkJzqGLZYlVGf1V7KWZb1I-IZceDsVfHuqV-Tx29eH2x_N3f33n7df7honQS0N6FagABDOmHEUnnuhOw1CKt8N3GtQtvNWtAawZX7wyjo9cNsqKQbpQIsr8umYu8vz87727mMoDqfJJpz3pQejtOiUquCHf8CneZ_rI0rPOdMguZQVuj5CLs-lZPT9Lodo86EH1q-b6P_eRDW8P6Xuh4jjGT99fQU-ngBbnJ18tsmFcua0MVzzNejzkSt2i-fR_tP2D-GfnSw</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>Farooq, N.</creator><creator>Priyamvada, S.</creator><creator>Khan, F.</creator><creator>Yusufi, A.N.K.</creator><general>SAGE Publications</general><general>Arnold</general><general>Sage Publications Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7ST</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>SOI</scope><scope>7QL</scope></search><sort><creationdate>20070701</creationdate><title>Time dependent effect of gentamicin on enzymes of carbohydrate metabolism and terminal digestion in rat intestine</title><author>Farooq, N. ; Priyamvada, S. ; Khan, F. ; Yusufi, A.N.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-1853e3113c99dd3f2f38681347f6b2f817a6fa3591e50fbf7ac8b2a5743b4c183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Alkaline Phosphatase - metabolism</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - toxicity</topic><topic>Antibacterial agents</topic><topic>Antibiotics</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Carbohydrate Metabolism - drug effects</topic><topic>Carbohydrates</topic><topic>Catalase - metabolism</topic><topic>Creatinine - blood</topic><topic>Digestion - drug effects</topic><topic>Eating - drug effects</topic><topic>Enzymes</topic><topic>Enzymes - metabolism</topic><topic>Fructose-Bisphosphatase - metabolism</topic><topic>gamma-Glutamyltransferase - metabolism</topic><topic>Gentamicins - toxicity</topic><topic>Glucose-6-Phosphatase - metabolism</topic><topic>Glucosephosphate Dehydrogenase - metabolism</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Intestinal Absorption - drug effects</topic><topic>Intestine, Small - drug effects</topic><topic>Intestine, Small - enzymology</topic><topic>Intestine, Small - metabolism</topic><topic>Isocitrate Dehydrogenase - metabolism</topic><topic>L-Lactate Dehydrogenase - metabolism</topic><topic>Large intestine</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Malate Dehydrogenase - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Side effects</topic><topic>Small intestine</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Time Factors</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farooq, N.</creatorcontrib><creatorcontrib>Priyamvada, S.</creatorcontrib><creatorcontrib>Khan, F.</creatorcontrib><creatorcontrib>Yusufi, A.N.K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environment Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Farooq, N.</au><au>Priyamvada, S.</au><au>Khan, F.</au><au>Yusufi, A.N.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Time dependent effect of gentamicin on enzymes of carbohydrate metabolism and terminal digestion in rat intestine</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>26</volume><issue>7</issue><spage>587</spage><epage>593</epage><pages>587-593</pages><issn>0960-3271</issn><eissn>1477-0903</eissn><abstract>Gentamicin (GM) is an aminoglycoside antibiotic commonly used against life threatening gram negative bacterial infections, however, nephrotoxicity remains the major concern for its long term use. Although its effects on kidney are well characterized but there have been no studies regarding its effects on intestine. We hypothesize that GM causes adaptive coordinated effect on enzymes of carbohydrate metabolism and terminal digestion/ absorption in rat intestine. Rats were administerd a nephrotoxic dose of GM (80 mg /kg body weight) daily for 15 days and a time dependent effect was observed on various enzyme activities. Activities of lactate (LDH), malate (MDH) and isocitrate (ICDH) dehydrogenases, significantly increased and peaked at different time intervals of GM treatment. Whereas LDH activity remained higher, MDH and ICDH activity slowly declined from their peak values. Activities of fructose-1,6-bisphosphatase, glucose-6-phosphatase and glucose-6-phosphate dehydrogenase increased but malic enzyme decreased in a time dependent manner. Activity of alkaline phosphatase and sucrase significantly increased but γ-glutamyl transpeptidase activity decreased. GM administration increased lipid peroxidation, glutathione peroxidase but decreased superoxide dismutase and catalase activities. The results indicate that GM treatment selectively upregulated certain enzymes of carbohydrate metabolism and terminal digestion/absorption and perturbed antioxidant defenses.
Human & Experimental Taxicology, (2007) 26, 587—593.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>17884963</pmid><doi>10.1177/09603271079544</doi><tpages>7</tpages></addata></record> |
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| subjects | Alkaline Phosphatase - metabolism Animals Anti-Bacterial Agents - toxicity Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Biochemistry Biological and medical sciences Body Weight - drug effects Carbohydrate Metabolism - drug effects Carbohydrates Catalase - metabolism Creatinine - blood Digestion - drug effects Eating - drug effects Enzymes Enzymes - metabolism Fructose-Bisphosphatase - metabolism gamma-Glutamyltransferase - metabolism Gentamicins - toxicity Glucose-6-Phosphatase - metabolism Glucosephosphate Dehydrogenase - metabolism Glutathione Peroxidase - metabolism Intestinal Absorption - drug effects Intestine, Small - drug effects Intestine, Small - enzymology Intestine, Small - metabolism Isocitrate Dehydrogenase - metabolism L-Lactate Dehydrogenase - metabolism Large intestine Lipid Peroxidation - drug effects Malate Dehydrogenase - metabolism Male Medical sciences Pharmacology. Drug treatments Rats Rats, Wistar Rodents Side effects Small intestine Superoxide Dismutase - metabolism Time Factors Toxicology |
| title | Time dependent effect of gentamicin on enzymes of carbohydrate metabolism and terminal digestion in rat intestine |
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