Understanding the transmission of foot-and-mouth disease virus at different scales

•FMDV is readily transmitted via direct and indirect contact between hosts.•The role of low-probability events is difficult to recreate and model.•Sequences can be combined with epidemic data to reconstruct transmission trees.•Improved models need to accommodate sampling biases and unsampled events....

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Current opinion in virology 2018-02, Vol.28, p.85-91
Hauptverfasser: Paton, David J, Gubbins, Simon, King, Donald P
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:•FMDV is readily transmitted via direct and indirect contact between hosts.•The role of low-probability events is difficult to recreate and model.•Sequences can be combined with epidemic data to reconstruct transmission trees.•Improved models need to accommodate sampling biases and unsampled events.•The very low risk of FMDV transmission from carriers remains poorly defined. Foot-and-mouth disease (FMD) is highly infectious, but despite the large quantities of FMD virus released into the environment and the extreme susceptibility of host species to infection, transmission is not always predictable. Whereas virus spread in endemic settings is characterised by frequent direct and indirect animal contacts, incursions into FMD-free countries may be seeded by low-probability events such as fomite or wind-borne aerosol routes. There remains a void between data generated from small-scale experimental studies and our ability to reliably reconstruct transmission routes at different scales between farms, countries and regions. This review outlines recent transmission studies in susceptible host species, and considers new approaches that integrate virus genomics and epidemiological data to recreate and understand the spread of FMD.
ISSN:1879-6257
1879-6265
DOI:10.1016/j.coviro.2017.11.013