Antitussive and expectorant activities of licorice and its major compounds
[Display omitted] Licorice has been used as an antitussive and expectorant herbal medicine for a long history. This work evaluated the activities of 14 major compounds and crude extracts of licorice, using the classical ammonia-induced cough model and phenol red secretion model in mice. Liquiritin a...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry 2018-01, Vol.26 (1), p.278-284 |
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| container_title | Bioorganic & medicinal chemistry |
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| creator | Kuang, Yi Li, Bin Fan, Jingran Qiao, Xue Ye, Min |
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Licorice has been used as an antitussive and expectorant herbal medicine for a long history. This work evaluated the activities of 14 major compounds and crude extracts of licorice, using the classical ammonia-induced cough model and phenol red secretion model in mice. Liquiritin apioside (1), liquiritin (2), and liquiritigenin (3) at 50 mg/kg (i.g.) could significantly decrease cough frequency by 30–78% (p |
| doi_str_mv | 10.1016/j.bmc.2017.11.046 |
| format | Article |
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Licorice has been used as an antitussive and expectorant herbal medicine for a long history. This work evaluated the activities of 14 major compounds and crude extracts of licorice, using the classical ammonia-induced cough model and phenol red secretion model in mice. Liquiritin apioside (1), liquiritin (2), and liquiritigenin (3) at 50 mg/kg (i.g.) could significantly decrease cough frequency by 30–78% (p < .01). The antitussive effects could be partially antagonized by the pretreatment of methysergide or glibenclamide, but not naloxone. Moreover, compounds 1–3 showed potent expectorant activities after 3 days treatment (p < .05). The water and ethanol extracts of licorice, which contain abundant 1 and 2, could decrease cough frequency at 200 mg/kg by 25–59% (p < .05), and enhance the phenol red secretion (p < .05), while the ethyl acetate extract showed little effect. These results indicate liquiritin apioside and liquiritin are the major antitussive and expectorant compounds of licorice. Their antitussive effects depend on both peripheral and central mechanisms.</description><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3391</identifier><identifier>DOI: 10.1016/j.bmc.2017.11.046</identifier><identifier>PMID: 29224994</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Administration, Oral ; Ammonia ; Animals ; Antitussive ; Antitussive Agents - antagonists & inhibitors ; Antitussive Agents - chemistry ; Antitussive Agents - pharmacology ; Cough ; Cough - chemically induced ; Cough - drug therapy ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Expectorant ; Expectorants - chemistry ; Expectorants - isolation & purification ; Expectorants - pharmacology ; Glyburide - pharmacology ; Glycyrrhiza - chemistry ; Herbal medicine ; Licorice ; Male ; Methysergide - pharmacology ; Mice ; Mice, Inbred ICR ; Molecular Structure ; Phenolsulfonphthalein - metabolism ; Plant Extracts - chemistry ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Structure-Activity Relationship</subject><ispartof>Bioorganic & medicinal chemistry, 2018-01, Vol.26 (1), p.278-284</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-165417c81e1a350e9019715daa529d8f16b3b6e8a55d01b4afb9acfa9816e7ff3</citedby><cites>FETCH-LOGICAL-c419t-165417c81e1a350e9019715daa529d8f16b3b6e8a55d01b4afb9acfa9816e7ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0968089617318539$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29224994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuang, Yi</creatorcontrib><creatorcontrib>Li, Bin</creatorcontrib><creatorcontrib>Fan, Jingran</creatorcontrib><creatorcontrib>Qiao, Xue</creatorcontrib><creatorcontrib>Ye, Min</creatorcontrib><title>Antitussive and expectorant activities of licorice and its major compounds</title><title>Bioorganic & medicinal chemistry</title><addtitle>Bioorg Med Chem</addtitle><description>[Display omitted]
Licorice has been used as an antitussive and expectorant herbal medicine for a long history. This work evaluated the activities of 14 major compounds and crude extracts of licorice, using the classical ammonia-induced cough model and phenol red secretion model in mice. Liquiritin apioside (1), liquiritin (2), and liquiritigenin (3) at 50 mg/kg (i.g.) could significantly decrease cough frequency by 30–78% (p < .01). The antitussive effects could be partially antagonized by the pretreatment of methysergide or glibenclamide, but not naloxone. Moreover, compounds 1–3 showed potent expectorant activities after 3 days treatment (p < .05). The water and ethanol extracts of licorice, which contain abundant 1 and 2, could decrease cough frequency at 200 mg/kg by 25–59% (p < .05), and enhance the phenol red secretion (p < .05), while the ethyl acetate extract showed little effect. These results indicate liquiritin apioside and liquiritin are the major antitussive and expectorant compounds of licorice. Their antitussive effects depend on both peripheral and central mechanisms.</description><subject>Administration, Oral</subject><subject>Ammonia</subject><subject>Animals</subject><subject>Antitussive</subject><subject>Antitussive Agents - antagonists & inhibitors</subject><subject>Antitussive Agents - chemistry</subject><subject>Antitussive Agents - pharmacology</subject><subject>Cough</subject><subject>Cough - chemically induced</subject><subject>Cough - drug therapy</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Expectorant</subject><subject>Expectorants - chemistry</subject><subject>Expectorants - isolation & purification</subject><subject>Expectorants - pharmacology</subject><subject>Glyburide - pharmacology</subject><subject>Glycyrrhiza - chemistry</subject><subject>Herbal medicine</subject><subject>Licorice</subject><subject>Male</subject><subject>Methysergide - pharmacology</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Molecular Structure</subject><subject>Phenolsulfonphthalein - metabolism</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Structure-Activity Relationship</subject><issn>0968-0896</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQQC0EoqXwA1hQRpYEXz6cWExVxacqscBsOc5FcpTExXYq-Pe4SmFkuhvePekeIddAE6DA7rqkHlSSUigTgITm7IQsIWd5nGUcTsmSclbFtOJsQS6c6yilac7hnCxSnoaN50vyuh699pNzeo-RHJsIv3aovLFy9JFUXu-11-gi00a9VsZqNWPau2iQnbGRMsPOTGPjLslZK3uHV8e5Ih-PD--b53j79vSyWW9jlQP3MbAih1JVgCCzgiKnwEsoGimLlDdVC6zOaoaVLIqGQp3LtuZStZJXwLBs22xFbmfvzprPCZ0Xg3YK-16OaCYngq4oeJqxLKAwo8oa5yy2Ymf1IO23ACoOCUUnQkJxSCgAREgYbm6O-qkesPm7-G0WgPsZwPDkXqMVTmkcFTbahnSiMfof_Q8LkoID</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Kuang, Yi</creator><creator>Li, Bin</creator><creator>Fan, Jingran</creator><creator>Qiao, Xue</creator><creator>Ye, Min</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180101</creationdate><title>Antitussive and expectorant activities of licorice and its major compounds</title><author>Kuang, Yi ; Li, Bin ; Fan, Jingran ; Qiao, Xue ; Ye, Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-165417c81e1a350e9019715daa529d8f16b3b6e8a55d01b4afb9acfa9816e7ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Administration, Oral</topic><topic>Ammonia</topic><topic>Animals</topic><topic>Antitussive</topic><topic>Antitussive Agents - antagonists & inhibitors</topic><topic>Antitussive Agents - chemistry</topic><topic>Antitussive Agents - pharmacology</topic><topic>Cough</topic><topic>Cough - chemically induced</topic><topic>Cough - drug therapy</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Expectorant</topic><topic>Expectorants - chemistry</topic><topic>Expectorants - isolation & purification</topic><topic>Expectorants - pharmacology</topic><topic>Glyburide - pharmacology</topic><topic>Glycyrrhiza - chemistry</topic><topic>Herbal medicine</topic><topic>Licorice</topic><topic>Male</topic><topic>Methysergide - pharmacology</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Molecular Structure</topic><topic>Phenolsulfonphthalein - metabolism</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuang, Yi</creatorcontrib><creatorcontrib>Li, Bin</creatorcontrib><creatorcontrib>Fan, Jingran</creatorcontrib><creatorcontrib>Qiao, Xue</creatorcontrib><creatorcontrib>Ye, Min</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuang, Yi</au><au>Li, Bin</au><au>Fan, Jingran</au><au>Qiao, Xue</au><au>Ye, Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antitussive and expectorant activities of licorice and its major compounds</atitle><jtitle>Bioorganic & medicinal chemistry</jtitle><addtitle>Bioorg Med Chem</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>26</volume><issue>1</issue><spage>278</spage><epage>284</epage><pages>278-284</pages><issn>0968-0896</issn><eissn>1464-3391</eissn><abstract>[Display omitted]
Licorice has been used as an antitussive and expectorant herbal medicine for a long history. This work evaluated the activities of 14 major compounds and crude extracts of licorice, using the classical ammonia-induced cough model and phenol red secretion model in mice. Liquiritin apioside (1), liquiritin (2), and liquiritigenin (3) at 50 mg/kg (i.g.) could significantly decrease cough frequency by 30–78% (p < .01). The antitussive effects could be partially antagonized by the pretreatment of methysergide or glibenclamide, but not naloxone. Moreover, compounds 1–3 showed potent expectorant activities after 3 days treatment (p < .05). The water and ethanol extracts of licorice, which contain abundant 1 and 2, could decrease cough frequency at 200 mg/kg by 25–59% (p < .05), and enhance the phenol red secretion (p < .05), while the ethyl acetate extract showed little effect. These results indicate liquiritin apioside and liquiritin are the major antitussive and expectorant compounds of licorice. Their antitussive effects depend on both peripheral and central mechanisms.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>29224994</pmid><doi>10.1016/j.bmc.2017.11.046</doi><tpages>7</tpages></addata></record> |
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| subjects | Administration, Oral Ammonia Animals Antitussive Antitussive Agents - antagonists & inhibitors Antitussive Agents - chemistry Antitussive Agents - pharmacology Cough Cough - chemically induced Cough - drug therapy Disease Models, Animal Dose-Response Relationship, Drug Expectorant Expectorants - chemistry Expectorants - isolation & purification Expectorants - pharmacology Glyburide - pharmacology Glycyrrhiza - chemistry Herbal medicine Licorice Male Methysergide - pharmacology Mice Mice, Inbred ICR Molecular Structure Phenolsulfonphthalein - metabolism Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Structure-Activity Relationship |
| title | Antitussive and expectorant activities of licorice and its major compounds |
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