Antitussive and expectorant activities of licorice and its major compounds

[Display omitted] Licorice has been used as an antitussive and expectorant herbal medicine for a long history. This work evaluated the activities of 14 major compounds and crude extracts of licorice, using the classical ammonia-induced cough model and phenol red secretion model in mice. Liquiritin a...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2018-01, Vol.26 (1), p.278-284
Hauptverfasser:	Kuang, Yi, Li, Bin, Fan, Jingran, Qiao, Xue, Ye, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Ammonia Animals Antitussive Antitussive Agents - antagonists & inhibitors Antitussive Agents - chemistry Antitussive Agents - pharmacology Cough Cough - chemically induced Cough - drug therapy Disease Models, Animal Dose-Response Relationship, Drug Expectorant Expectorants - chemistry Expectorants - isolation & purification Expectorants - pharmacology Glyburide - pharmacology Glycyrrhiza - chemistry Herbal medicine Licorice Male Methysergide - pharmacology Mice Mice, Inbred ICR Molecular Structure Phenolsulfonphthalein - metabolism Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Structure-Activity Relationship
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Zusammenfassung:	[Display omitted] Licorice has been used as an antitussive and expectorant herbal medicine for a long history. This work evaluated the activities of 14 major compounds and crude extracts of licorice, using the classical ammonia-induced cough model and phenol red secretion model in mice. Liquiritin apioside (1), liquiritin (2), and liquiritigenin (3) at 50 mg/kg (i.g.) could significantly decrease cough frequency by 30–78% (p
ISSN:	0968-0896 1464-3391
DOI:	10.1016/j.bmc.2017.11.046