Candida albicans Infection Delays Duodenal Ulcer Healing in Cysteamine-Induced Duodenal Ulcers in Rats

A low curability of ulcers infected with Candida has been reported in the literature. The aim of the study reported here was to investigate experimentally whether Candida infection affects the healing of ulcers. Candida albicans (the Candida group) or saline (the control group) was administered intr...

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Veröffentlicht in:	Digestive diseases and sciences 2008-11, Vol.53 (11), p.2878-2885
Hauptverfasser:	Jin, Longxue, Yoshida, Masashi, Nakamura, Tetsuya, Ishikawa, Hideki, Wakabayashi, Go, Tanabe, Minoru, Kawachi, Shigeyuki, Shinoda, Masahiro, Saikawa, Yoshiro, Wada, Norihito, Kameyama, Kaori, Kumai, Koichiro, Kubota, Tetsuro, Sano, Katsuko, Nagao, Keisuke, Amagai, Masayuki, Kitagawa, Yuko, Kitajima, Masaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biological and medical sciences Candida albicans Candida albicans - pathogenicity Candidiasis - complications Cysteamine Disease Models, Animal Duodenal Ulcer - chemically induced Duodenal Ulcer - microbiology Duodenal Ulcer - physiopathology Duodenum - metabolism Duodenum - microbiology Duodenum - pathology Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Hepatology Male Medical sciences Medicine Medicine & Public Health Oncology Original Article Other diseases. Semiology Proliferating Cell Nuclear Antigen - metabolism Rats Rats, Wistar Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Time Factors Transplant Surgery Vascular Endothelial Growth Factor A - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems Wound Healing - physiology
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Zusammenfassung:	A low curability of ulcers infected with Candida has been reported in the literature. The aim of the study reported here was to investigate experimentally whether Candida infection affects the healing of ulcers. Candida albicans (the Candida group) or saline (the control group) was administered intragastrically into rats with a cysteamine-induced duodenal ulcer. The duodenal lesions, vascular endothelial growth factor A (VEGF-A) and proliferating cell nuclear antigen (PCNA) were assessed. On Day 7 post-administration, 70.4% rats of the Candida group had a duodenal ulcer compared with 33.3% in the control group ( P
ISSN:	0163-2116 1573-2568
DOI:	10.1007/s10620-008-0385-9