Synthesis of novel 5,6-substituted furo[2,3- d]pyrimidines via Pd-catalyzed cyclization of alkynylpyrimidinols with aryl iodides

A flexible method for the synthesis of 5,6-disubstituted furo[2,3- d]pyrimidine derivatives is described. The key step is a palladium-catalyzed arylative cyclization of alkynylpyrimidinols with various aryl iodides, which gave the title compounds in 36–75% yield. A flexible method for the synthesis of 5,6-disubstituted furo[2,3- d]pyrimidine derivatives is described. The key step is a palladium-catalyzed arylative cyclization of alkynylpyrimidinols with various aryl iodides, which gave the title compounds in 36–75% yield. [Display omitted]