Organocatalytic asymmetric chlorinative dearomatization of naphthols

Organocatalytic asymmetric chlorinative dearomatization of naphthols

An organocatalytic asymmetric chlorinative dearomatization of naphthols was realized for the first time, providing chiral naphthalenones with a Cl-containing all-substituted stereocenter in excellent yields and enantioselectivity (up to 97% yield and 96% ee). The reaction features mild reaction cond...

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Veröffentlicht in:Chemical science (Cambridge) 2015-07, Vol.6 (7), p.4179-4183
Hauptverfasser: Yin, Qin, Wang, Shou-Guo, Liang, Xiao-Wei, Gao, De-Wei, Zheng, Jun, You, Shu-Li
Format: Artikel
Sprache:eng
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Zusammenfassung:An organocatalytic asymmetric chlorinative dearomatization of naphthols was realized for the first time, providing chiral naphthalenones with a Cl-containing all-substituted stereocenter in excellent yields and enantioselectivity (up to 97% yield and 96% ee). The reaction features mild reaction conditions, good tolerance of diverse functional groups and simple reaction operation.
ISSN:2041-6520
2041-6539
DOI:10.1039/c5sc00494b