Improved developmental competence in embryos treated with lycopene during in vitro culture system

In vitro embryo development remains suboptimal compared to in vivo development due to the challenge from various stressors associated with in vitro culturing of oocytes. When 0.2 μM lycopene was added to oocyte in vitro maturation and embryo culture media, to assess its antioxidant effects on embryo...

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Veröffentlicht in:	Molecular reproduction and development 2018-01, Vol.85 (1), p.46-61
Hauptverfasser:	Chowdhury, M.M.R., Mesalam, Ayman, Khan, Imran, Joo, Myeong‐Don, Lee, Kyeong‐Lim, Xu, Lianguang, Afrin, Fahmida, Kong, Il‐Keun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl-CoA dehydrogenase Acyl-CoA Dehydrogenase, Long-Chain - biosynthesis Animals Antioxidants Antioxidants - pharmacology Apoptosis Blastocyst - cytology Blastocysts Bone Morphogenetic Protein 15 - biosynthesis bovine embryo Caspase Caspase 3 - analysis Caspase 9 - analysis Caspase-3 Caspase-9 Cattle Cell culture Coenzyme A Ligases - biosynthesis Culture media Dehydrogenase Dehydrogenases Embryo Culture Techniques Embryonic Development - drug effects Embryos Growth Differentiation Factor 9 - biosynthesis I-kappa B Kinase - biosynthesis IκBKB Lipid peroxidation Lycopene Lycopene - pharmacology Mitochondria NADH NADH dehydrogenase NADH Dehydrogenase - biosynthesis Nuclei Oocytes Oocytes - growth & development oxidative stress Peroxidation Reactive oxygen species Superoxide dismutase Superoxide Dismutase - biosynthesis Supplements Transcription Trophectoderm
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Zusammenfassung:	In vitro embryo development remains suboptimal compared to in vivo development due to the challenge from various stressors associated with in vitro culturing of oocytes. When 0.2 μM lycopene was added to oocyte in vitro maturation and embryo culture media, to assess its antioxidant effects on embryo development, we observed a significant (p
ISSN:	1040-452X 1098-2795
DOI:	10.1002/mrd.22937