A central role for free heme in the pathogenesis of severe malaria: the missing link?

Malaria, the disease caused by Plasmodium infection, is endemic to poverty in so-called underdeveloped countries. Plasmodium falciparum , the main infectious Plasmodium species in sub-Saharan countries, can trigger the development of severe malaria, including cerebral malaria, a neurological syndrom...

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Veröffentlicht in:	Journal of molecular medicine (Berlin, Germany) Germany), 2008-10, Vol.86 (10), p.1097-1111
Hauptverfasser:	Ferreira, Ana, Balla, József, Jeney, Viktória, Balla, György, Soares, Miguel P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Carbon Monoxide - metabolism Disease Models, Animal General aspects Heme - metabolism Heme - physiology Heme Oxygenase-1 - metabolism Hemoglobins - metabolism Human Genetics Human protozoal diseases Humans Infectious diseases Internal Medicine Malaria Malaria - enzymology Malaria - metabolism Malaria - physiopathology Malaria, Cerebral - enzymology Malaria, Cerebral - metabolism Malaria, Cerebral - physiopathology Medical sciences Models, Biological Molecular Medicine Parasitic diseases Plasmodium falciparum Protozoal diseases Review
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Beschreibung
Zusammenfassung:	Malaria, the disease caused by Plasmodium infection, is endemic to poverty in so-called underdeveloped countries. Plasmodium falciparum , the main infectious Plasmodium species in sub-Saharan countries, can trigger the development of severe malaria, including cerebral malaria, a neurological syndrome that claims the lives of more than one million children (
ISSN:	0946-2716 1432-1440
DOI:	10.1007/s00109-008-0368-5