A genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependence

A genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependence

Neuroticism is a personality trait which reflects individual differences in emotional stability and vulnerability to stress and anxiety. Consistent evidence shows substantial genetic influences on variation in this trait. The present study seeks to identify regions containing susceptibility loci for...

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Veröffentlicht in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2007-06, Vol.144B (4), p.463-468
Hauptverfasser: Kuo, Po-Hsiu, Neale, Michael C., Riley, Brien P., Patterson, Diana G., Walsh, Dermot, Prescott, Carol A., Kendler, Kenneth S.
Format: Artikel
Sprache:eng
Schlagworte:
Alcoholism - genetics
Alcoholism and acute alcohol poisoning
Biological and medical sciences
Classical genetics, quantitative genetics, hybrids
emotional stability
European Continental Ancestry Group - genetics
Female
Fundamental and applied biological sciences. Psychology
Genetic Linkage
Genetic Markers
Genetics of eukaryotes. Biological and molecular evolution
Genome, Human - genetics
Human
Humans
internalizing
Ireland
Male
Medical genetics
Medical sciences
negative affect
Neurotic Disorders - genetics
Personality - genetics
quantitative genetics
Sex Characteristics
Siblings - psychology
susceptibility loci
Toxicology
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Zusammenfassung:Neuroticism is a personality trait which reflects individual differences in emotional stability and vulnerability to stress and anxiety. Consistent evidence shows substantial genetic influences on variation in this trait. The present study seeks to identify regions containing susceptibility loci for neuroticism using a selected sib‐pair sample from Ireland. Using Merlin regress, we conducted a 4 cM whole‐genome linkage analysis on 714 sib‐pairs. Evidence for linkage to neuroticism was found on chromosomes 11p, 12q, and 15q. The highest linkage peak was on 12q at marker D12S1638 with a Lod score of 2.13 (−log p = 2.76, empirical P‐value
ISSN:1552-4841
1552-485X
DOI:10.1002/ajmg.b.30478