Hint1 is a haplo-insufficient tumor suppressor in mice

The HINT1 protein, a member of the histidine triad (HIT) family, is highly conserved in diverse species and ubiquitously expressed in mammalian tissues. However, its precise function in mammalian cells is not known. As a result of its structural similarity to the tumor-suppressor protein FHIT, we us...

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Veröffentlicht in:	Oncogene 2006-02, Vol.25 (5), p.713-721
Hauptverfasser:	Li, H, Zhang, Y, Su, T, Santella, R M, Weinstein, I B
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene Animals Apoptosis Base Sequence Biological and medical sciences Cancer Cell Biology Cell division Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes DNA Primers Female Fundamental and applied biological sciences. Psychology Genes, Tumor Suppressor Haplotypes Human Genetics Internal Medicine Kinases Mammary Neoplasms, Experimental - chemically induced Mammary Neoplasms, Experimental - genetics Medicine Medicine & Public Health Mice Molecular and cellular biology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Oncology original-article Ovarian Neoplasms - chemically induced Ovarian Neoplasms - genetics Proteins Tumorigenesis Tumors
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Zusammenfassung:	The HINT1 protein, a member of the histidine triad (HIT) family, is highly conserved in diverse species and ubiquitously expressed in mammalian tissues. However, its precise function in mammalian cells is not known. As a result of its structural similarity to the tumor-suppressor protein FHIT, we used homozygous-deleted Hint1 mice to study its role in tumorigenesis. We discovered that after 2 to 3 years of age the spontaneous tumor incidence in Hint1 −/− mice was significantly greater than that in wild-type Hint1 +/+ mice ( P
ISSN:	0950-9232 1476-5594
DOI:	10.1038/sj.onc.1209111