The association with cardiovascular disease and type 2 diabetes in adults with atopic dermatitis: a systematic review and meta‐analysis
Summary Background Recent studies examining the association between atopic dermatitis (AD) and cardiovascular disease (CVD) and type 2 diabetes have shown inconsistent results. Objectives To carry out a systematic review and meta‐analysis that examines the association with cardiovascular disease and...
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Veröffentlicht in: | British journal of dermatology (1951) 2018-06, Vol.178 (6), p.1272-1279 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Summary
Background
Recent studies examining the association between atopic dermatitis (AD) and cardiovascular disease (CVD) and type 2 diabetes have shown inconsistent results.
Objectives
To carry out a systematic review and meta‐analysis that examines the association with cardiovascular disease and type 2 diabetes in adults with AD.
Methods
We compared the risk of CVD and diabetes for adult patients with and without AD by searching the PubMed, Embase and Web of Science databases. Data extraction was carried out by two independent reviewers. We found a total of 2855 citations, of which 53 were considered relevant based on title and . Overall, 16 publications were included in the qualitative analysis, of which 13 were also included in a quantitative meta‐analysis of crude data.
Results
No association was observed between AD and unspecified but suspected type 2 diabetes [pooled odds ratio (OR) 1·11; 95% confidence interval (CI) 0·87–1·42], hypertension (pooled OR 1·16; 95% CI 0·98–1·37), stroke (pooled OR 1·15; 95% CI 0·95–1·39) or myocardial infarction (pooled OR 1·14; 95% CI 0·83–1·56), but a positive association was observed with angina pectoris (OR 1·73; 95% CI 1·27–2·37). Meta‐analysis of adjusted data gave similar results.
Conclusions
While adults with AD in some populations have an increased prevalence of cardiovascular risk factors, such as obesity and smoking, it is unlikely that AD represents an independent and clinically relevant risk factor for cardiometabolic disease.
What's already known about this topic?
Atopic dermatitis has been associated with atopic, psychiatric and autoimmune comorbidities.
Recent studies investigating a possible association with cardiovascular comorbidities and type 2 diabetes have produced conflicting results.
What does this study add?
Based on a systematic review and meta‐analysis, atopic dermatitis is unlikely to represent an independent risk factor for cardiometabolic disease.
Observed differences in risk estimates between North American and European studies may be explained by variations in cardiovascular risk factors such as body weight.
Linked Comment: Drucker and Flohr. Br J Dermatol 2018; 178:1235–1236.
Plain language summary available online |
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ISSN: | 0007-0963 1365-2133 |
DOI: | 10.1111/bjd.16215 |