Increased trophoblast inclusions in placentas from prematurely born infants: A potential marker of risk for preterm neurodevelopmental outcomes

Increased trophoblast inclusions in placentas from prematurely born infants: A potential marker of risk for preterm neurodevelopmental outcomes

Trophoblast inclusions (TIs) are placental abnormalities of the trophoblast bilayer. Present in 2–8% of full-term placentas, they are associated with poor neurodevelopment, including autism. Although previously unstudied, examination of chorionic villi from 108 preterm births revealed a ∼4 fold incr...

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Veröffentlicht in:Placenta (Eastbourne) 2017-12, Vol.60, p.61-63
Hauptverfasser: Firestein, Morgan R., Abellar, Rosanna, Myers, Michael M., Welch, Martha G.
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers
Chorioamnionitis
Female
Humans
Infant, Newborn
Infant, Premature
Neurodevelopmental risk
Placenta
Placenta - pathology
Pregnancy
Premature Birth - pathology
Preterm birth
Trophoblast inclusions
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Zusammenfassung:Trophoblast inclusions (TIs) are placental abnormalities of the trophoblast bilayer. Present in 2–8% of full-term placentas, they are associated with poor neurodevelopment, including autism. Although previously unstudied, examination of chorionic villi from 108 preterm births revealed a ∼4 fold increase in the frequency of TIs (30.5%). Frequency of TIs was inversely related to gestational age (GA); 43% of placentas
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2017.10.006