Safety evaluation of polyphenols extracted from hop bracts

Hop bract polyphenols contain polyphenols as promising functional ingredients. To assess the safety of topical hop bract polyphenols, Hopsphenon ®, we examined acute, 14-day, 28-day and 90-day toxicity tests in rats, and mutagenicity tests using Ames test and micronucleus test in mice. The acute, 14...

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Veröffentlicht in:	Food and chemical toxicology 2007-08, Vol.45 (8), p.1383-1392
Hauptverfasser:	Nagasako-Akazome, Yoko, Honma, Daiki, Tagashira, Motoyuki, Kanda, Tomomasa, Yasue, Masaaki, Ohtake, Yasuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	90-day toxicity and 28-day recovery test acute toxicity Acute toxicity test animal models Animals Biological and medical sciences Blood Cell Count Blood Chemical Analysis bracts Female Flavonoids - toxicity herbs Hop bract polyphenols hops Hopsphenon Humulus - chemistry Male Medical sciences medicinal plants mice mutagenicity Mutagenicity test Mutagenicity Tests - methods Organ Size perennials Phenols - toxicity plant extracts Plant Extracts - toxicity Polyphenols Procyanidins Rats Rats, Sprague-Dawley Rats, Wistar safety testing Specific Pathogen-Free Organisms toxicity testing Toxicology Urinalysis
Online-Zugang:	Volltext
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