Skeletal muscle from aged American Quarter Horses shows impairments in mitochondrial biogenesis and expression of autophagy markers

Aging is associated with decreased mitochondrial content and function in skeletal muscle, possibly due to compromised biogenesis and autophagic removal of dysfunctional mitochondria. The aim of this study was to compare markers of mitochondrial content and biogenesis and of autophagy between skeleta...

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Veröffentlicht in:	Experimental gerontology 2018-02, Vol.102, p.19-27
Hauptverfasser:	Li, Chengcheng, White, Sarah H., Warren, Lori K., Wohlgemuth, Stephanie E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aging Aging - genetics Aging - metabolism Aging - pathology Animals Autophagosomes - metabolism Autophagosomes - pathology Autophagy Autophagy-Related Proteins - genetics Autophagy-Related Proteins - metabolism DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism Female Gene Expression Regulation Horses - genetics Horses - metabolism Lysosomes - metabolism Lysosomes - pathology Male Mitochondria, Muscle - genetics Mitochondria, Muscle - metabolism Mitochondria, Muscle - pathology Mitochondrial content mtDNA copy number Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Organelle Biogenesis Signal Transduction Skeletal muscle
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Zusammenfassung:	Aging is associated with decreased mitochondrial content and function in skeletal muscle, possibly due to compromised biogenesis and autophagic removal of dysfunctional mitochondria. The aim of this study was to compare markers of mitochondrial content and biogenesis and of autophagy between skeletal muscle from young and aged American Quarter Horses. Citrate synthase protein and mtDNA copy number were decreased in triceps brachii (TB) muscle (P
ISSN:	0531-5565 1873-6815
DOI:	10.1016/j.exger.2017.11.022