Dimeric sesquiterpenoid-4H-chromone derivatives from agarwood of Aquilaria crassna and their cytotoxicity

Six previously undescribed uncommon ester-bonded dimeric compounds (aquilacrassnins A–F) containing a sesquiterpenoid and a 5,6,7,8-tetrahydroxy-2-(2-phenylethyl)-5,6,7,8-tetrahydro -4H-chromone units were isolated from the EtOAc extract of agarwood originating from Aquilaria crassna. Their structur...

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Veröffentlicht in:Phytochemistry (Oxford) 2018-01, Vol.145, p.207-213
Hauptverfasser: Yang, Yang, Chen, Hui-Qin, Kong, Fan-Dong, Zhou, Li-Man, Li, Wei, Dong, Wen-Hua, Chen, Zhi-Bao, Mei, Wen-Li, Dai, Hao-Fu
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Sprache:eng
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Zusammenfassung:Six previously undescribed uncommon ester-bonded dimeric compounds (aquilacrassnins A–F) containing a sesquiterpenoid and a 5,6,7,8-tetrahydroxy-2-(2-phenylethyl)-5,6,7,8-tetrahydro -4H-chromone units were isolated from the EtOAc extract of agarwood originating from Aquilaria crassna. Their structures were elucidated by spectroscopic (NMR, UV, IR, MS, and ECD) methods. All the compounds were tested for AChE inhibitory activity and cytotoxicity against K562, BEL-7402, SGC-7901, Hela, and A549 tumor cell lines. The results showed that aquilacrassnin A, B, and E exhibited weak cytotoxicity against the five tested cell lines, whereas all the compounds were inactive against AChE. Phytochemistry investigations on Aquilaria crassna originated agarwood led to the isolation of six previously undescribed dimeric sesquiterpenoid-4H-chromone derivatives. [Display omitted] •Six previously undescribed compounds were isolated from agarwood of Aquilaria crassna.•The dimers of sesquiterpenoid-4H-chromones are a relatively unusual class of chemical components.•Aquilacrassnin A, B and E exhibited weak cytotoxicity against the tested cell lines.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2017.08.007