Caryophyllane Thiols, Vinyl Thioethers, Di‐ and Bis‐Sulfides: Antioxidant and Membrane Protective Activities

Caryophyllane thioterpenoids were synthesized in 23 – 81% yields. The antioxidant properties of the obtained compounds in various model systems were found. It was revealed that 4,5‐epoxycaryophyll‐9‐ylmethanethiol has the greatest antioxidant activity. The isomerism of sesquiterpenic fragments was s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemistry & biodiversity 2017-12, Vol.14 (12), p.n/a
Hauptverfasser:	Gyrdymova, Yulia V., Sudarikov, Denis V., Shevchenko, Oksana G., Rubtsova, Svetlana A., Slepukhin, Pavel A., Kutchin, Aleksandr V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidant activity Antioxidants Antioxidants - chemical synthesis Antioxidants - chemistry Biological activity Biological effects Brain - drug effects Brain - metabolism Caryophyllene oxide Erythrocytes - cytology Erythrocytes - drug effects Erythrocytes - metabolism Hemolysis - drug effects Hydrogen Peroxide - toxicity Isomerism Isomerization Lipid Peroxidation - drug effects Magnetic Resonance Spectroscopy Membrane protective activity Mice Molecular Conformation Oxidation-Reduction Oxyhemoglobins - chemistry Sesquiterpenes - chemical synthesis Sesquiterpenes - chemistry Sulfhydryl Compounds - chemistry Sulfides - chemistry ThioeThers Thiols Thiosesquterpenoids Vinyl Compounds - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Caryophyllane thioterpenoids were synthesized in 23 – 81% yields. The antioxidant properties of the obtained compounds in various model systems were found. It was revealed that 4,5‐epoxycaryophyll‐9‐ylmethanethiol has the greatest antioxidant activity. The isomerism of sesquiterpenic fragments was shown to have a significant effect on the biological activity of the compounds.
ISSN:	1612-1872 1612-1880
DOI:	10.1002/cbdv.201700296