Tetrachlorosilane catalyzed multicomponent one-step fusion of biopertinent pyrimidine heterocycles
Multicomponent one-step fusion of a variety of pharmacologically pertinent pyrimidine heterocycles has efficiently been achieved from their respective aldehydes, β-dicarbonyl compounds, and urea/thiourea in the presence of a catalytic amount of tetrachlorosilane in DMF/AN mixture at normal ambient t...
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| Veröffentlicht in: | Tetrahedron 2008-05, Vol.64 (22), p.5023-5031 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Multicomponent one-step fusion of a variety of pharmacologically pertinent pyrimidine heterocycles has efficiently been achieved from their respective aldehydes, β-dicarbonyl compounds, and urea/thiourea in the presence of a catalytic amount of tetrachlorosilane in DMF/AN mixture at normal ambient temperature.
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| ISSN: | 0040-4020 1464-5416 |
| DOI: | 10.1016/j.tet.2008.03.078 |