Ultrasensitive Chemiluminescent Detection of Cathepsin B: Insights into the New Frontier of Chemiluminescent Imaging

Ultrasensitive Chemiluminescent Detection of Cathepsin B: Insights into the New Frontier of Chemiluminescent Imaging

Let there be light: Chemiluminescence provides a bright detection signal against a dark background and offers an excellent signal‐to‐noise ratio for analysis. Now, a chemiluminescent probe for cathepsin B has been developed that provides a 16,000‐fold improvement in sensitivity for detecting proteas...

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Veröffentlicht in:Angewandte Chemie International Edition 2018-01, Vol.57 (3), p.622-624
Hauptverfasser: Ryan, Lucas S., Lippert, Alexander R.
Format: Artikel
Sprache:eng
Schlagworte:
1,2-dioxetane
Background noise
bioimaging
cathepsin B
Chemiluminescence
imaging agents
Proteases
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Zusammenfassung:Let there be light: Chemiluminescence provides a bright detection signal against a dark background and offers an excellent signal‐to‐noise ratio for analysis. Now, a chemiluminescent probe for cathepsin B has been developed that provides a 16,000‐fold improvement in sensitivity for detecting protease activity.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201711228