Early postnatal development of electrophysiological and histological properties of sensory sural nerves in male rats that were maternally deprived and artificially reared: Role of tactile stimulation

ABSTRACT Early adverse experiences disrupt brain development and behavior, but little is known about how such experiences impact on the development of the peripheral nervous system. Recently, we found alterations in the electrophysiological and histological characteristics of the sensory sural (SU)...

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Veröffentlicht in:Developmental neurobiology (Hoboken, N.J.) N.J.), 2018-04, Vol.78 (4), p.351-362
Hauptverfasser: Zempoalteca, Rene, Porras, Mercedes G., Moreno‐Pérez, Suelem, Ramirez‐Funez, Gabriela, Aguirre‐Benítez, Elsa L., González del Pliego, Margarita, Mariscal‐Tovar, Silvia, Mendoza‐Garrido, Maria E., Hoffman, Kurt Leroy, Jiménez‐Estrada, Ismael, Melo, Angel I.
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container_issue 4
container_start_page 351
container_title Developmental neurobiology (Hoboken, N.J.)
container_volume 78
creator Zempoalteca, Rene
Porras, Mercedes G.
Moreno‐Pérez, Suelem
Ramirez‐Funez, Gabriela
Aguirre‐Benítez, Elsa L.
González del Pliego, Margarita
Mariscal‐Tovar, Silvia
Mendoza‐Garrido, Maria E.
Hoffman, Kurt Leroy
Jiménez‐Estrada, Ismael
Melo, Angel I.
description ABSTRACT Early adverse experiences disrupt brain development and behavior, but little is known about how such experiences impact on the development of the peripheral nervous system. Recently, we found alterations in the electrophysiological and histological characteristics of the sensory sural (SU) nerve in maternally deprived, artificially reared (AR) adult male rats, as compared with maternally reared (MR) control rats. In the present study, our aim was to characterize the ontogeny of these alterations. Thus, male pups of four postnatal days (PND) were (1) AR group, (2) AR and received daily tactile stimulation to the body and anogenital region (AR‐Tactile group); or (3) reared by their mother (MR group). At PND 7, 14, or 21, electrophysiological properties and histological characteristics of the SU nerves were assessed. At PND 7, the electrophysiological properties and most histological parameters of the SU nerve did not differ among MR, AR, and AR‐Tactile groups. By contrast, at PND 14 and/or 21, the SU nerve of AR rats showed a lower CAP amplitude and area, and a significant reduction in myelin area and myelin thickness, which were accompanied by a reduction in axon area (day 21 only) compared to the nerves of MR rats. Tactile stimulation (AR‐Tactile group) partially prevented most of these alterations. These results suggest that sensory cues from the mother and/or littermates during the first 7–14 PND are relevant for the proper development and function of the adult SU nerve. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 351–362, 2018
doi_str_mv 10.1002/dneu.22561
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Recently, we found alterations in the electrophysiological and histological characteristics of the sensory sural (SU) nerve in maternally deprived, artificially reared (AR) adult male rats, as compared with maternally reared (MR) control rats. In the present study, our aim was to characterize the ontogeny of these alterations. Thus, male pups of four postnatal days (PND) were (1) AR group, (2) AR and received daily tactile stimulation to the body and anogenital region (AR‐Tactile group); or (3) reared by their mother (MR group). At PND 7, 14, or 21, electrophysiological properties and histological characteristics of the SU nerves were assessed. At PND 7, the electrophysiological properties and most histological parameters of the SU nerve did not differ among MR, AR, and AR‐Tactile groups. By contrast, at PND 14 and/or 21, the SU nerve of AR rats showed a lower CAP amplitude and area, and a significant reduction in myelin area and myelin thickness, which were accompanied by a reduction in axon area (day 21 only) compared to the nerves of MR rats. Tactile stimulation (AR‐Tactile group) partially prevented most of these alterations. These results suggest that sensory cues from the mother and/or littermates during the first 7–14 PND are relevant for the proper development and function of the adult SU nerve. © 2017 Wiley Periodicals, Inc. 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source Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; EZB Electronic Journals Library
subjects Animal behavior
Anogenital
artificial rearing
compound action potential
maternal deprivation
Myelin
myelination
Nervous system
Ontogeny
Peripheral nervous system
postnatal experience
Rats
Rodents
Sensory properties
sensory sural nerve
Stimulation
Tactile
tactile stimulation
Tactile stimuli
title Early postnatal development of electrophysiological and histological properties of sensory sural nerves in male rats that were maternally deprived and artificially reared: Role of tactile stimulation
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