Early postnatal development of electrophysiological and histological properties of sensory sural nerves in male rats that were maternally deprived and artificially reared: Role of tactile stimulation
ABSTRACT Early adverse experiences disrupt brain development and behavior, but little is known about how such experiences impact on the development of the peripheral nervous system. Recently, we found alterations in the electrophysiological and histological characteristics of the sensory sural (SU)...
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Veröffentlicht in: | Developmental neurobiology (Hoboken, N.J.) N.J.), 2018-04, Vol.78 (4), p.351-362 |
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creator | Zempoalteca, Rene Porras, Mercedes G. Moreno‐Pérez, Suelem Ramirez‐Funez, Gabriela Aguirre‐Benítez, Elsa L. González del Pliego, Margarita Mariscal‐Tovar, Silvia Mendoza‐Garrido, Maria E. Hoffman, Kurt Leroy Jiménez‐Estrada, Ismael Melo, Angel I. |
description | ABSTRACT
Early adverse experiences disrupt brain development and behavior, but little is known about how such experiences impact on the development of the peripheral nervous system. Recently, we found alterations in the electrophysiological and histological characteristics of the sensory sural (SU) nerve in maternally deprived, artificially reared (AR) adult male rats, as compared with maternally reared (MR) control rats. In the present study, our aim was to characterize the ontogeny of these alterations. Thus, male pups of four postnatal days (PND) were (1) AR group, (2) AR and received daily tactile stimulation to the body and anogenital region (AR‐Tactile group); or (3) reared by their mother (MR group). At PND 7, 14, or 21, electrophysiological properties and histological characteristics of the SU nerves were assessed. At PND 7, the electrophysiological properties and most histological parameters of the SU nerve did not differ among MR, AR, and AR‐Tactile groups. By contrast, at PND 14 and/or 21, the SU nerve of AR rats showed a lower CAP amplitude and area, and a significant reduction in myelin area and myelin thickness, which were accompanied by a reduction in axon area (day 21 only) compared to the nerves of MR rats. Tactile stimulation (AR‐Tactile group) partially prevented most of these alterations. These results suggest that sensory cues from the mother and/or littermates during the first 7–14 PND are relevant for the proper development and function of the adult SU nerve. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 351–362, 2018 |
doi_str_mv | 10.1002/dneu.22561 |
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Early adverse experiences disrupt brain development and behavior, but little is known about how such experiences impact on the development of the peripheral nervous system. Recently, we found alterations in the electrophysiological and histological characteristics of the sensory sural (SU) nerve in maternally deprived, artificially reared (AR) adult male rats, as compared with maternally reared (MR) control rats. In the present study, our aim was to characterize the ontogeny of these alterations. Thus, male pups of four postnatal days (PND) were (1) AR group, (2) AR and received daily tactile stimulation to the body and anogenital region (AR‐Tactile group); or (3) reared by their mother (MR group). At PND 7, 14, or 21, electrophysiological properties and histological characteristics of the SU nerves were assessed. At PND 7, the electrophysiological properties and most histological parameters of the SU nerve did not differ among MR, AR, and AR‐Tactile groups. By contrast, at PND 14 and/or 21, the SU nerve of AR rats showed a lower CAP amplitude and area, and a significant reduction in myelin area and myelin thickness, which were accompanied by a reduction in axon area (day 21 only) compared to the nerves of MR rats. Tactile stimulation (AR‐Tactile group) partially prevented most of these alterations. These results suggest that sensory cues from the mother and/or littermates during the first 7–14 PND are relevant for the proper development and function of the adult SU nerve. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 351–362, 2018</description><identifier>ISSN: 1932-8451</identifier><identifier>EISSN: 1932-846X</identifier><identifier>DOI: 10.1002/dneu.22561</identifier><identifier>PMID: 29197166</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animal behavior ; Anogenital ; artificial rearing ; compound action potential ; maternal deprivation ; Myelin ; myelination ; Nervous system ; Ontogeny ; Peripheral nervous system ; postnatal experience ; Rats ; Rodents ; Sensory properties ; sensory sural nerve ; Stimulation ; Tactile ; tactile stimulation ; Tactile stimuli</subject><ispartof>Developmental neurobiology (Hoboken, N.J.), 2018-04, Vol.78 (4), p.351-362</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3571-3b8e8f4cd35e821ac8e129a7be735944df5e0f6323aab2c7d6903c6b5081b70a3</citedby><cites>FETCH-LOGICAL-c3571-3b8e8f4cd35e821ac8e129a7be735944df5e0f6323aab2c7d6903c6b5081b70a3</cites><orcidid>0000-0003-4842-7217</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdneu.22561$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdneu.22561$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29197166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zempoalteca, Rene</creatorcontrib><creatorcontrib>Porras, Mercedes G.</creatorcontrib><creatorcontrib>Moreno‐Pérez, Suelem</creatorcontrib><creatorcontrib>Ramirez‐Funez, Gabriela</creatorcontrib><creatorcontrib>Aguirre‐Benítez, Elsa L.</creatorcontrib><creatorcontrib>González del Pliego, Margarita</creatorcontrib><creatorcontrib>Mariscal‐Tovar, Silvia</creatorcontrib><creatorcontrib>Mendoza‐Garrido, Maria E.</creatorcontrib><creatorcontrib>Hoffman, Kurt Leroy</creatorcontrib><creatorcontrib>Jiménez‐Estrada, Ismael</creatorcontrib><creatorcontrib>Melo, Angel I.</creatorcontrib><title>Early postnatal development of electrophysiological and histological properties of sensory sural nerves in male rats that were maternally deprived and artificially reared: Role of tactile stimulation</title><title>Developmental neurobiology (Hoboken, N.J.)</title><addtitle>Dev Neurobiol</addtitle><description>ABSTRACT
Early adverse experiences disrupt brain development and behavior, but little is known about how such experiences impact on the development of the peripheral nervous system. Recently, we found alterations in the electrophysiological and histological characteristics of the sensory sural (SU) nerve in maternally deprived, artificially reared (AR) adult male rats, as compared with maternally reared (MR) control rats. In the present study, our aim was to characterize the ontogeny of these alterations. Thus, male pups of four postnatal days (PND) were (1) AR group, (2) AR and received daily tactile stimulation to the body and anogenital region (AR‐Tactile group); or (3) reared by their mother (MR group). At PND 7, 14, or 21, electrophysiological properties and histological characteristics of the SU nerves were assessed. At PND 7, the electrophysiological properties and most histological parameters of the SU nerve did not differ among MR, AR, and AR‐Tactile groups. By contrast, at PND 14 and/or 21, the SU nerve of AR rats showed a lower CAP amplitude and area, and a significant reduction in myelin area and myelin thickness, which were accompanied by a reduction in axon area (day 21 only) compared to the nerves of MR rats. Tactile stimulation (AR‐Tactile group) partially prevented most of these alterations. These results suggest that sensory cues from the mother and/or littermates during the first 7–14 PND are relevant for the proper development and function of the adult SU nerve. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 351–362, 2018</description><subject>Animal behavior</subject><subject>Anogenital</subject><subject>artificial rearing</subject><subject>compound action potential</subject><subject>maternal deprivation</subject><subject>Myelin</subject><subject>myelination</subject><subject>Nervous system</subject><subject>Ontogeny</subject><subject>Peripheral nervous system</subject><subject>postnatal experience</subject><subject>Rats</subject><subject>Rodents</subject><subject>Sensory properties</subject><subject>sensory sural nerve</subject><subject>Stimulation</subject><subject>Tactile</subject><subject>tactile stimulation</subject><subject>Tactile stimuli</subject><issn>1932-8451</issn><issn>1932-846X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kcuKFDEUhoMozji68QEk4EaEHnOpqzsZ2wsMCuKAu-JUcsrOkErKJNVDPaGvZbpr7IULVzmc8-VPzv8T8pyzS86YeKMdzpdClBV_QM55K8WmKaofD091yc_IkxhvGSulqNhjciZa3ta8qs7J7y0Eu9DJx-QggaUa92j9NKJL1A8ULaoU_LRbovHW_zQqM-A03ZmYTo0pExiSwXi4E9FFHxYa55BnDsM-942jI1ikAVKkaQeJ3mHA3EsYHNj8B41TMHvUR3nIaoNR5jgJCAH1W_rNZ4H8QAKVTC5jMuNsIRnvnpJHA9iIz-7PC3LzYfv96tPm-uvHz1fvrjdKljXfyL7BZiiUliU2goNqkIsW6h5rWbZFoYcS2VBJIQF6oWpdtUyqqi9Zw_uagbwgr1bdvPKvGWPqRhMVWgsO_Ry71deW8SKjL_9Bb_182DV2gvG6FjmYKlOvV0oFH2PAocsujBCWjrPuEG93iLc7xpvhF_eScz-iPqF_88wAX4G77M_yH6nu_ZftzSr6Byn0teg</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Zempoalteca, Rene</creator><creator>Porras, Mercedes G.</creator><creator>Moreno‐Pérez, Suelem</creator><creator>Ramirez‐Funez, Gabriela</creator><creator>Aguirre‐Benítez, Elsa L.</creator><creator>González del Pliego, Margarita</creator><creator>Mariscal‐Tovar, Silvia</creator><creator>Mendoza‐Garrido, Maria E.</creator><creator>Hoffman, Kurt Leroy</creator><creator>Jiménez‐Estrada, Ismael</creator><creator>Melo, Angel I.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4842-7217</orcidid></search><sort><creationdate>201804</creationdate><title>Early postnatal development of electrophysiological and histological properties of sensory sural nerves in male rats that were maternally deprived and artificially reared: Role of tactile stimulation</title><author>Zempoalteca, Rene ; Porras, Mercedes G. ; Moreno‐Pérez, Suelem ; Ramirez‐Funez, Gabriela ; Aguirre‐Benítez, Elsa L. ; González del Pliego, Margarita ; Mariscal‐Tovar, Silvia ; Mendoza‐Garrido, Maria E. ; Hoffman, Kurt Leroy ; Jiménez‐Estrada, Ismael ; Melo, Angel I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3571-3b8e8f4cd35e821ac8e129a7be735944df5e0f6323aab2c7d6903c6b5081b70a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animal behavior</topic><topic>Anogenital</topic><topic>artificial rearing</topic><topic>compound action potential</topic><topic>maternal deprivation</topic><topic>Myelin</topic><topic>myelination</topic><topic>Nervous system</topic><topic>Ontogeny</topic><topic>Peripheral nervous system</topic><topic>postnatal experience</topic><topic>Rats</topic><topic>Rodents</topic><topic>Sensory properties</topic><topic>sensory sural nerve</topic><topic>Stimulation</topic><topic>Tactile</topic><topic>tactile stimulation</topic><topic>Tactile stimuli</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zempoalteca, Rene</creatorcontrib><creatorcontrib>Porras, Mercedes G.</creatorcontrib><creatorcontrib>Moreno‐Pérez, Suelem</creatorcontrib><creatorcontrib>Ramirez‐Funez, Gabriela</creatorcontrib><creatorcontrib>Aguirre‐Benítez, Elsa L.</creatorcontrib><creatorcontrib>González del Pliego, Margarita</creatorcontrib><creatorcontrib>Mariscal‐Tovar, Silvia</creatorcontrib><creatorcontrib>Mendoza‐Garrido, Maria E.</creatorcontrib><creatorcontrib>Hoffman, Kurt Leroy</creatorcontrib><creatorcontrib>Jiménez‐Estrada, Ismael</creatorcontrib><creatorcontrib>Melo, Angel I.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental neurobiology (Hoboken, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zempoalteca, Rene</au><au>Porras, Mercedes G.</au><au>Moreno‐Pérez, Suelem</au><au>Ramirez‐Funez, Gabriela</au><au>Aguirre‐Benítez, Elsa L.</au><au>González del Pliego, Margarita</au><au>Mariscal‐Tovar, Silvia</au><au>Mendoza‐Garrido, Maria E.</au><au>Hoffman, Kurt Leroy</au><au>Jiménez‐Estrada, Ismael</au><au>Melo, Angel I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early postnatal development of electrophysiological and histological properties of sensory sural nerves in male rats that were maternally deprived and artificially reared: Role of tactile stimulation</atitle><jtitle>Developmental neurobiology (Hoboken, N.J.)</jtitle><addtitle>Dev Neurobiol</addtitle><date>2018-04</date><risdate>2018</risdate><volume>78</volume><issue>4</issue><spage>351</spage><epage>362</epage><pages>351-362</pages><issn>1932-8451</issn><eissn>1932-846X</eissn><abstract>ABSTRACT
Early adverse experiences disrupt brain development and behavior, but little is known about how such experiences impact on the development of the peripheral nervous system. Recently, we found alterations in the electrophysiological and histological characteristics of the sensory sural (SU) nerve in maternally deprived, artificially reared (AR) adult male rats, as compared with maternally reared (MR) control rats. In the present study, our aim was to characterize the ontogeny of these alterations. Thus, male pups of four postnatal days (PND) were (1) AR group, (2) AR and received daily tactile stimulation to the body and anogenital region (AR‐Tactile group); or (3) reared by their mother (MR group). At PND 7, 14, or 21, electrophysiological properties and histological characteristics of the SU nerves were assessed. At PND 7, the electrophysiological properties and most histological parameters of the SU nerve did not differ among MR, AR, and AR‐Tactile groups. By contrast, at PND 14 and/or 21, the SU nerve of AR rats showed a lower CAP amplitude and area, and a significant reduction in myelin area and myelin thickness, which were accompanied by a reduction in axon area (day 21 only) compared to the nerves of MR rats. Tactile stimulation (AR‐Tactile group) partially prevented most of these alterations. These results suggest that sensory cues from the mother and/or littermates during the first 7–14 PND are relevant for the proper development and function of the adult SU nerve. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 351–362, 2018</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29197166</pmid><doi>10.1002/dneu.22561</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-4842-7217</orcidid></addata></record> |
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subjects | Animal behavior Anogenital artificial rearing compound action potential maternal deprivation Myelin myelination Nervous system Ontogeny Peripheral nervous system postnatal experience Rats Rodents Sensory properties sensory sural nerve Stimulation Tactile tactile stimulation Tactile stimuli |
title | Early postnatal development of electrophysiological and histological properties of sensory sural nerves in male rats that were maternally deprived and artificially reared: Role of tactile stimulation |
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