CCDC104 Antibodies and Mitosis of Cancer Cells

We have previously identified cancer patients with the paraneoplastic antibody, anti-Yo and the less characterized antibody, anti-CCDC104 (coiled-coil domain containing protein 104, also referred to as CFAP36 or BARTL1) [1]. CCDC104 has been localized to both the nucleus and cytoplasm of neuroblastoma cells [1] and the protein may have a role in the formation of cellular cilia [2, 3]. Anti-Yo consists of antibodies against cerebellar degeneration related protein 2 (CDR2) and cerebellar degeneration related protein 2 like (CDR2L), respectively [4, 5]. This article is protected by copyright. All rights reserved.