In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions
In our study, we have tested six acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, HI‐6, trimedoxime, BI‐6 and Hlö‐7) for reactivation of sarin‐ and cyclosarin‐inhibited AChE using an in vitro reactivation test. We have used rat brain homogenate as the suitable source of enzyme. All...
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| Veröffentlicht in: | Journal of applied toxicology 2005-07, Vol.25 (4), p.296-300 |
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| creator | Kuca, Kamil Cabal, Jiri Jun, Daniel Kassa, Jiri Bartosová, Lucie Kunesová, Gabriela |
| description | In our study, we have tested six acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, HI‐6, trimedoxime, BI‐6 and Hlö‐7) for reactivation of sarin‐ and cyclosarin‐inhibited AChE using an in vitro reactivation test. We have used rat brain homogenate as the suitable source of enzyme. All oximes are able to reactivate sarin‐inhibited AChE. On the other hand, only HI‐6 is able to reactivate satisfactorily cyclosarin‐inhibited AChE. Copyright © 2005 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/jat.1065 |
| format | Article |
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We have used rat brain homogenate as the suitable source of enzyme. All oximes are able to reactivate sarin‐inhibited AChE. On the other hand, only HI‐6 is able to reactivate satisfactorily cyclosarin‐inhibited AChE. Copyright © 2005 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0260-437X</identifier><identifier>EISSN: 1099-1263</identifier><identifier>DOI: 10.1002/jat.1065</identifier><identifier>PMID: 16025528</identifier><identifier>CODEN: JJATDK</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>acetylcholinesterase ; Animals ; Biological and medical sciences ; Brain - drug effects ; Brain - enzymology ; Chemical and industrial products toxicology. Toxic occupational diseases ; Chemical Warfare Agents - toxicity ; Cholinesterase Inhibitors - toxicity ; Cholinesterase Reactivators - pharmacology ; cyclosarin ; Gas, fumes ; Kinetics ; Medical sciences ; nerve agents ; Organophosphorus Compounds - toxicity ; oxime ; Rats ; Rats, Wistar ; reactivation ; sarin ; Sarin - toxicity ; Toxicology</subject><ispartof>Journal of applied toxicology, 2005-07, Vol.25 (4), p.296-300</ispartof><rights>Copyright © 2005 John Wiley & Sons, Ltd.</rights><rights>2005 INIST-CNRS</rights><rights>Copyright (c) 2005 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4185-5b57e68bac1c33e5f663b6320a81d2f1681aa65dc82580eac9098ba9332433873</citedby><cites>FETCH-LOGICAL-c4185-5b57e68bac1c33e5f663b6320a81d2f1681aa65dc82580eac9098ba9332433873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjat.1065$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjat.1065$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16942720$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16025528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuca, Kamil</creatorcontrib><creatorcontrib>Cabal, Jiri</creatorcontrib><creatorcontrib>Jun, Daniel</creatorcontrib><creatorcontrib>Kassa, Jiri</creatorcontrib><creatorcontrib>Bartosová, Lucie</creatorcontrib><creatorcontrib>Kunesová, Gabriela</creatorcontrib><title>In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions</title><title>Journal of applied toxicology</title><addtitle>J. Appl. Toxicol</addtitle><description>In our study, we have tested six acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, HI‐6, trimedoxime, BI‐6 and Hlö‐7) for reactivation of sarin‐ and cyclosarin‐inhibited AChE using an in vitro reactivation test. We have used rat brain homogenate as the suitable source of enzyme. All oximes are able to reactivate sarin‐inhibited AChE. On the other hand, only HI‐6 is able to reactivate satisfactorily cyclosarin‐inhibited AChE. Copyright © 2005 John Wiley & Sons, Ltd.</description><subject>acetylcholinesterase</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - enzymology</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Chemical Warfare Agents - toxicity</subject><subject>Cholinesterase Inhibitors - toxicity</subject><subject>Cholinesterase Reactivators - pharmacology</subject><subject>cyclosarin</subject><subject>Gas, fumes</subject><subject>Kinetics</subject><subject>Medical sciences</subject><subject>nerve agents</subject><subject>Organophosphorus Compounds - toxicity</subject><subject>oxime</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>reactivation</subject><subject>sarin</subject><subject>Sarin - toxicity</subject><subject>Toxicology</subject><issn>0260-437X</issn><issn>1099-1263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10c9P2zAUB3BrAo3SIe0vQL5s4hLmH7XjHBEajAqBphXRm_XiOMOQ2sVOYfnv56rR2IWTbfnj956-RugzJaeUEPbtEfq8keIDmlBSVQVlku-hCWGSFDNeLg_QYUqPhOQ7pj6iAyoJE4KpCRquPH5xfQw4WjC9e4HeBY_XobfeDDi0OIWVxWBsP3TmIXTO29TbCMm-vQgxYfgNzqceJ4jOFxh8g81gurA7O99sjG2w8w-udtsW6RPab6FL9mhcp-ju4vvi_EdxfXt5dX52XZgZVaIQtSitVDUYaji3opWS15IzAoo2rKVSUQApGqOYUCRPVJEq64pzNuNclXyKvu7qrmN43uTh9colY7sOvA2bpGlVUqaEyvBkB00MKUXb6nV0K4iDpkRvY9Y5Zr2NOdPjseamXtnmDY65ZvBlBJAMdG0Eb1z6z1UzVjKSXbFzr66zw7sN9fxsMTYevcuf8Oefh_ikZclLoe9vLnW1mP_k98tfesn_AtuupRY</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>Kuca, Kamil</creator><creator>Cabal, Jiri</creator><creator>Jun, Daniel</creator><creator>Kassa, Jiri</creator><creator>Bartosová, Lucie</creator><creator>Kunesová, Gabriela</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>200507</creationdate><title>In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions</title><author>Kuca, Kamil ; Cabal, Jiri ; Jun, Daniel ; Kassa, Jiri ; Bartosová, Lucie ; Kunesová, Gabriela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4185-5b57e68bac1c33e5f663b6320a81d2f1681aa65dc82580eac9098ba9332433873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>acetylcholinesterase</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - enzymology</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Chemical Warfare Agents - toxicity</topic><topic>Cholinesterase Inhibitors - toxicity</topic><topic>Cholinesterase Reactivators - pharmacology</topic><topic>cyclosarin</topic><topic>Gas, fumes</topic><topic>Kinetics</topic><topic>Medical sciences</topic><topic>nerve agents</topic><topic>Organophosphorus Compounds - toxicity</topic><topic>oxime</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>reactivation</topic><topic>sarin</topic><topic>Sarin - toxicity</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuca, Kamil</creatorcontrib><creatorcontrib>Cabal, Jiri</creatorcontrib><creatorcontrib>Jun, Daniel</creatorcontrib><creatorcontrib>Kassa, Jiri</creatorcontrib><creatorcontrib>Bartosová, Lucie</creatorcontrib><creatorcontrib>Kunesová, Gabriela</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuca, Kamil</au><au>Cabal, Jiri</au><au>Jun, Daniel</au><au>Kassa, Jiri</au><au>Bartosová, Lucie</au><au>Kunesová, Gabriela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions</atitle><jtitle>Journal of applied toxicology</jtitle><addtitle>J. Appl. Toxicol</addtitle><date>2005-07</date><risdate>2005</risdate><volume>25</volume><issue>4</issue><spage>296</spage><epage>300</epage><pages>296-300</pages><issn>0260-437X</issn><eissn>1099-1263</eissn><coden>JJATDK</coden><abstract>In our study, we have tested six acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, HI‐6, trimedoxime, BI‐6 and Hlö‐7) for reactivation of sarin‐ and cyclosarin‐inhibited AChE using an in vitro reactivation test. We have used rat brain homogenate as the suitable source of enzyme. All oximes are able to reactivate sarin‐inhibited AChE. On the other hand, only HI‐6 is able to reactivate satisfactorily cyclosarin‐inhibited AChE. Copyright © 2005 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>16025528</pmid><doi>10.1002/jat.1065</doi><tpages>5</tpages></addata></record> |
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| subjects | acetylcholinesterase Animals Biological and medical sciences Brain - drug effects Brain - enzymology Chemical and industrial products toxicology. Toxic occupational diseases Chemical Warfare Agents - toxicity Cholinesterase Inhibitors - toxicity Cholinesterase Reactivators - pharmacology cyclosarin Gas, fumes Kinetics Medical sciences nerve agents Organophosphorus Compounds - toxicity oxime Rats Rats, Wistar reactivation sarin Sarin - toxicity Toxicology |
| title | In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions |
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