In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions

In our study, we have tested six acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, HI‐6, trimedoxime, BI‐6 and Hlö‐7) for reactivation of sarin‐ and cyclosarin‐inhibited AChE using an in vitro reactivation test. We have used rat brain homogenate as the suitable source of enzyme. All...

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Veröffentlicht in:	Journal of applied toxicology 2005-07, Vol.25 (4), p.296-300
Hauptverfasser:	Kuca, Kamil, Cabal, Jiri, Jun, Daniel, Kassa, Jiri, Bartosová, Lucie, Kunesová, Gabriela
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholinesterase Animals Biological and medical sciences Brain - drug effects Brain - enzymology Chemical and industrial products toxicology. Toxic occupational diseases Chemical Warfare Agents - toxicity Cholinesterase Inhibitors - toxicity Cholinesterase Reactivators - pharmacology cyclosarin Gas, fumes Kinetics Medical sciences nerve agents Organophosphorus Compounds - toxicity oxime Rats Rats, Wistar reactivation sarin Sarin - toxicity Toxicology
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Zusammenfassung:	In our study, we have tested six acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, HI‐6, trimedoxime, BI‐6 and Hlö‐7) for reactivation of sarin‐ and cyclosarin‐inhibited AChE using an in vitro reactivation test. We have used rat brain homogenate as the suitable source of enzyme. All oximes are able to reactivate sarin‐inhibited AChE. On the other hand, only HI‐6 is able to reactivate satisfactorily cyclosarin‐inhibited AChE. Copyright © 2005 John Wiley & Sons, Ltd.
ISSN:	0260-437X 1099-1263
DOI:	10.1002/jat.1065