Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children
Objectives The enamelin gene ( ENAM ) polymorphism (rs12640848) was recently associated with dental caries in primary teeth in Polish children. The aims of the present study were to prove this association in primary dentition and to find a possible effect of this variant on caries development in per...
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Veröffentlicht in: | Clinical oral investigations 2018-05, Vol.22 (4), p.1873-1877 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Objectives
The
enamelin
gene (
ENAM
) polymorphism (rs12640848) was recently associated with dental caries in primary teeth in Polish children. The aims of the present study were to prove this association in primary dentition and to find a possible effect of this variant on caries development in permanent dentition in Czech children.
Materials and methods
This study comprised 905 Czech children. Totally, 187 children aged 2–6 years with primary dentition [78 healthy subjects (with decayed/missing/filled teeth, dmft = 0) and 109 patients with early childhood caries (ECC; dmft ≥ 1)] were included in this case-control study. In addition, 177 subjects aged 13–15 years without caries (DMFT = 0) and 541 children with dental caries (DMFT ≥ 1) in permanent dentition were selected from the ELSPAC study. Genotype determination of the
ENAM
polymorphism (rs12640848) was based on the TaqMan method.
Results
No significant differences in the allele or genotype frequencies between the caries-free children and those affected by dental caries were observed in both primary and permanent dentitions.
Conclusions
Lack of association between the
ENAM
polymorphism (rs12640848) and dental caries in Czech children was detected.
Clinical relevance
Although
ENAM
is considered as a candidate gene for dental caries, the presence of the
ENAM
variant (rs12640848) cannot be used as a risk factor of this multifactorial disease in the Czech population. |
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ISSN: | 1432-6981 1436-3771 |
DOI: | 10.1007/s00784-017-2280-2 |