Bone-targeting poly(ethylene sodium phosphate)

Bone-targeting poly(ethylene sodium phosphate)

Poly(ethylene sodium phosphate) (PEP·Na) showed excellent cytocompatibility and in vivo bone affinity. Moreover, PEP·Na did not interact with thrombin, which is a coagulation-related protein. Because immobilization of therapeutic agents and imaging probes on PEP·Na is easily performed, PEP·Na is a p...

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Veröffentlicht in:Biomaterials science 2018-01, Vol.6 (1), p.91-95
Hauptverfasser: Iwasaki, Yasuhiko, Yokota, Atsushi, Otaka, Akihisa, Inoue, Naoyuki, Yamaguchi, Akane, Yoshitomi, Toru, Yoshimoto, Keitaro, Neo, Masashi
Format: Artikel
Sprache:eng
Schlagworte:
Biocompatibility
Bone and Bones
Chemical compounds
Ethylene
Pharmacology
Polyethylenes - chemistry
Polymers - chemistry
Sodium phosphate
Thrombin
Thrombin - chemistry
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Zusammenfassung:Poly(ethylene sodium phosphate) (PEP·Na) showed excellent cytocompatibility and in vivo bone affinity. Moreover, PEP·Na did not interact with thrombin, which is a coagulation-related protein. Because immobilization of therapeutic agents and imaging probes on PEP·Na is easily performed, PEP·Na is a promising polymer for bone-targeted therapies.
ISSN:2047-4830
2047-4849
DOI:10.1039/c7bm00930e