TPL2 kinase action and control of inflammation

[Display omitted] Tumor progression locus 2 (TPL2, also known as COT or MAP3K8) is a mitogen-activated protein kinase kinase (MAP3K) activated downstream of TNFαR, IL1R, TLR, CD40, IL17R, and some GPCRs. TPL2 regulates the MEK1/2 and ERK1/2 pathways to regulate a cascade of inflammatory responses. I...

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Veröffentlicht in:	Pharmacological research 2018-03, Vol.129, p.188-193
Hauptverfasser:	Xu, Daqi, Matsumoto, Marissa L., McKenzie, Brent S., Zarrin, Ali A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune disease Autoimmunity COPD COT ERK Humans IBD Inflammation Inflammation - metabolism Macrophage MAP Kinase Kinase Kinases - chemistry MAP Kinase Kinase Kinases - physiology MAP3K8 MAPK Multiple sclerosis Neutrophil p38 Phosphorylation Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins - physiology Psoriasis Rheumatoid arthritis TLRs TNFα TPL2
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