TPL2 kinase action and control of inflammation

TPL2 kinase action and control of inflammation

[Display omitted] Tumor progression locus 2 (TPL2, also known as COT or MAP3K8) is a mitogen-activated protein kinase kinase (MAP3K) activated downstream of TNFαR, IL1R, TLR, CD40, IL17R, and some GPCRs. TPL2 regulates the MEK1/2 and ERK1/2 pathways to regulate a cascade of inflammatory responses. I...

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Veröffentlicht in:Pharmacological research 2018-03, Vol.129, p.188-193
Hauptverfasser: Xu, Daqi, Matsumoto, Marissa L., McKenzie, Brent S., Zarrin, Ali A.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Autoimmune disease
Autoimmunity
COPD
COT
ERK
Humans
IBD
Inflammation
Inflammation - metabolism
Macrophage
MAP Kinase Kinase Kinases - chemistry
MAP Kinase Kinase Kinases - physiology
MAP3K8
MAPK
Multiple sclerosis
Neutrophil
p38
Phosphorylation
Proto-Oncogene Proteins - chemistry
Proto-Oncogene Proteins - physiology
Psoriasis
Rheumatoid arthritis
TLRs
TNFα
TPL2
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Zusammenfassung:[Display omitted] Tumor progression locus 2 (TPL2, also known as COT or MAP3K8) is a mitogen-activated protein kinase kinase (MAP3K) activated downstream of TNFαR, IL1R, TLR, CD40, IL17R, and some GPCRs. TPL2 regulates the MEK1/2 and ERK1/2 pathways to regulate a cascade of inflammatory responses. In parallel to this, TPL2 also activates p38α and p38δ to drive the production of various inflammatory mediators in neutrophils. We discuss the implications of this finding in the context of various inflammatory diseases.
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2017.11.031