Prospect of Using Cell Product for the Therapy of Skin Defects in Diabetes Mellitus

The effectiveness of autologous cell product in the therapy of skin burn wounds was studied in C57B1/6 male mice against the background of streptozotocin-induced diabetes mellitus. In animals with and without modeled diabetes mellitus, significant decrease in skin defect area was observed after sing...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2017-12, Vol.164 (2), p.266-268
Hauptverfasser:	Lykov, A. P., Bondarenko, N. A., Poveshchenko, O. V., Miller, T. V., Poveshchenko, A. F., Surovtseva, M. A., Bgatova, N. P., Konenkov, V. I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Autografts Biomedical and Life Sciences Biomedicine Bone marrow Cell Biology Dermatologic agents Diabetes Diabetes mellitus Diabetes therapy Diabetic foot Fibroblasts Internal Medicine Laboratory Medicine Mesenchymal stem cells Mesenchyme Neovascularization Pathology Rodents Skin Skin care Stem cells Streptozocin Stromal cells Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine) Wounds
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Zusammenfassung:	The effectiveness of autologous cell product in the therapy of skin burn wounds was studied in C57B1/6 male mice against the background of streptozotocin-induced diabetes mellitus. In animals with and without modeled diabetes mellitus, significant decrease in skin defect area was observed after single administration of the cell product (bone marrow multipotent mesenchymal stromal cells, fibroblasts or media conditioned by these cells).
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-017-3970-0