Three-dimensional imaging and analysis of entire peripheral nerves after repair and reconstruction

[Display omitted] •Micro-scale details of 3D nerve fiber and vessel reorganization upon repair.•Distinct differentiation between nerve and connective tissue in a label-free manner.•Perineurium membranes and small capillaries visualized with isotropic 4μm resolution.•Quantitative measures proved sign...

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Veröffentlicht in:	Journal of neuroscience methods 2018-02, Vol.295, p.37-44
Hauptverfasser:	Bikis, Christos, Degrugillier, Lucas, Thalmann, Peter, Schulz, Georg, Müller, Bert, Hieber, Simone E., Kalbermatten, Daniel F., Madduri, Srinivas
Format:	Artikel
Sprache:	eng
Schlagworte:	3D imaging Absorbable Implants Anatomy Animals Axonal regeneration Capillaries - diagnostic imaging Capillaries - surgery Connective Tissue - diagnostic imaging Connective Tissue - surgery Female Imaging, Three-Dimensional - methods Micrometer Morphology Nerve conduits Nerve reconstruction Neurosurgical Procedures Non-destructive Peripheral Nerves - diagnostic imaging Peripheral Nerves - surgery Rats, Sprague-Dawley Reconstructive Surgical Procedures X-Ray Microtomography - methods X-ray tomography μCT
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Zusammenfassung:	[Display omitted] •Micro-scale details of 3D nerve fiber and vessel reorganization upon repair.•Distinct differentiation between nerve and connective tissue in a label-free manner.•Perineurium membranes and small capillaries visualized with isotropic 4μm resolution.•Quantitative measures proved significance for assessing repair quality, p
ISSN:	0165-0270 1872-678X
DOI:	10.1016/j.jneumeth.2017.11.015