Methylation changes and pathways affected in preterm birth: a role for SLC6A3 in neurodevelopment

Methylation changes and pathways affected in preterm birth: a role for SLC6A3 in neurodevelopment

To analyze whether preterm newborns show differences in methylation patterns in comparison to full-term newborns in white blood cells. Anthropometrical, biochemical features and methylation levels of preterm newborns (n = 24) and full-term newborns (n = 22) recruited in La Paz University Hospital (S...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Epigenomics 2018-01, Vol.10 (1), p.91-103
Hauptverfasser: Arpón, Ana, Milagro, Fermín I, Laja, Ana, Segura, Víctor, de Pipaón, Miguel Sáenz, Riezu-Boj, José-Ignacio, Alfredo Martínez, J
Format: Artikel
Sprache:eng
Schlagworte:
Attention deficit hyperactivity disorder
Biomarkers
Chronic illnesses
CpG Islands
DNA Methylation
Dopamine Plasma Membrane Transport Proteins - genetics
Epigenetics
Female
Gestational age
Humans
Hyperactivity
Infant, Premature
Leukocytes
Leukocytes - metabolism
Male
Neonates
Nervous System - growth & development
Neurodevelopmental disorders
Nutrition
Premature birth
Risk analysis
Risk factors
Statistical analysis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:To analyze whether preterm newborns show differences in methylation patterns in comparison to full-term newborns in white blood cells. Anthropometrical, biochemical features and methylation levels of preterm newborns (n = 24) and full-term newborns (n = 22) recruited in La Paz University Hospital (Spain) were assessed at 12 months of gestational age, whereas Bayley Scale of Infant Development was evaluated at 24/36 months. From all the statistically significant CpGs, methylation levels of cg00997378 (SLC6A3 gene) showed the highest differences (p 
ISSN:1750-1911
1750-192X
DOI:10.2217/epi-2017-0082