Amexanthomycins A–J, pentangular polyphenols produced by Amycolatopsis mediterranei S699∆rifA

Ten new pentangular polyphenols, namely amexanthomycins A–J ( 1 – 10 ) were isolated from the strain Amycolatopsis mediterranei S699∆ rifA constructed by deleting the polyketide synthase genes responsible for the biosynthesis of rifamycins. Their structures were elucidated on the basis of 1D and 2D...

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Veröffentlicht in:	Applied microbiology and biotechnology 2018, Vol.102 (2), p.689-702
Hauptverfasser:	Li, Xiaomei, Wu, Xingkang, Zhu, Jing, Shen, Yuemao
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycetales - chemistry Actinomycetales - genetics Amycolatopsis mediterranei Biomedical and Life Sciences Biosynthesis Biotechnological Products and Process Engineering Biotechnology Cloning, Molecular Deoxyribonucleic acid DNA DNA topoisomerase Genes, Bacterial Humans Life Sciences Microbial Genetics and Genomics Microbiology Multienzyme Complexes - metabolism Multigene Family NMR Nuclear magnetic resonance Open Reading Frames Polyketide synthase Polyketide Synthases - genetics Polyphenols Polyphenols - biosynthesis Polyphenols - chemistry Polyphenols - isolation & purification Rifamycins Sequence Analysis, DNA Topoisomerase Inhibitors - chemistry Topoisomerase Inhibitors - isolation & purification
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Zusammenfassung:	Ten new pentangular polyphenols, namely amexanthomycins A–J ( 1 – 10 ) were isolated from the strain Amycolatopsis mediterranei S699∆ rifA constructed by deleting the polyketide synthase genes responsible for the biosynthesis of rifamycins. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic data and high-resolution ESIMS. Amexanthomycins A–C ( 1 – 3 ) showed inhibitory activity against human DNA topoisomerases.
ISSN:	0175-7598 1432-0614
DOI:	10.1007/s00253-017-8648-z