Irgarol inhibits the synthesis of ATP in mitochondria from rat liver
The interactions of Irgarol with rat liver mithocondrial have been investigated. The results indicate that Irgarol inhibits the ATP synthesis. The analysis of the various steps involved in the ATP synthesis suggests that the inhibition is due to the opening of small-size pores.
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| Veröffentlicht in: | Chemosphere (Oxford) 2006-12, Vol.65 (10), p.1898-1903 |
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| container_issue | 10 |
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| container_title | Chemosphere (Oxford) |
| container_volume | 65 |
| creator | Bragadin, Marcantonio Cima, Francesca Ballarin, Loriano Manente, Sabrina |
| description | The interactions of Irgarol with rat liver mithocondrial have been investigated. The results indicate that Irgarol inhibits the ATP synthesis. The analysis of the various steps involved in the ATP synthesis suggests that the inhibition is due to the opening of small-size pores. |
| doi_str_mv | 10.1016/j.chemosphere.2006.08.001 |
| format | Article |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adenosine Triphosphatases - antagonists & inhibitors Adenosine Triphosphatases - drug effects Adenosine Triphosphate - biosynthesis Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone - pharmacology Cell Respiration - drug effects Dose-Response Relationship, Drug Ecotoxicology, biological effects of pollution Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology General aspects Intracellular Membranes - drug effects Irgarol Mithocondria Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Oligomycins - pharmacology Permeability Pollution Protons Rats Rats, Wistar Toxicity Triazines - administration & dosage Triazines - adverse effects Uncoupling Agents - pharmacology |
| title | Irgarol inhibits the synthesis of ATP in mitochondria from rat liver |
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