Irgarol inhibits the synthesis of ATP in mitochondria from rat liver

The interactions of Irgarol with rat liver mithocondrial have been investigated. The results indicate that Irgarol inhibits the ATP synthesis. The analysis of the various steps involved in the ATP synthesis suggests that the inhibition is due to the opening of small-size pores.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemosphere (Oxford) 2006-12, Vol.65 (10), p.1898-1903
Hauptverfasser:	Bragadin, Marcantonio, Cima, Francesca, Ballarin, Loriano, Manente, Sabrina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - antagonists & inhibitors Adenosine Triphosphatases - drug effects Adenosine Triphosphate - biosynthesis Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone - pharmacology Cell Respiration - drug effects Dose-Response Relationship, Drug Ecotoxicology, biological effects of pollution Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology General aspects Intracellular Membranes - drug effects Irgarol Mithocondria Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Oligomycins - pharmacology Permeability Pollution Protons Rats Rats, Wistar Toxicity Triazines - administration & dosage Triazines - adverse effects Uncoupling Agents - pharmacology
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Beschreibung
Zusammenfassung:	The interactions of Irgarol with rat liver mithocondrial have been investigated. The results indicate that Irgarol inhibits the ATP synthesis. The analysis of the various steps involved in the ATP synthesis suggests that the inhibition is due to the opening of small-size pores.
ISSN:	0045-6535 1879-1298
DOI:	10.1016/j.chemosphere.2006.08.001