A novel immunosuppressive pathway involving peroxynitrate-mediated nitration of platelet antigens within antigen-presenting cells

BACKGROUND: Studies have demonstrated that immunity against platelet (PLT) transfusions is dependent on recipient antigen‐presenting cells (APCs) and their ability to produce nitric oxide (NO). To further analyze this, we focused on NO's major metabolite peroxynitrite (ONOO‐) and its ability to...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2008-09, Vol.48 (9), p.1917-1924
Hauptverfasser:	Semple, John W., Speck, Edwin R., Fabron Jr, Antonio, Kim, Rukhsana Aslam Michael, Freedman, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood coagulation. Blood cells Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Fundamental and applied biological sciences. Psychology Medical sciences Molecular and cellular biology Platelet Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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Zusammenfassung:	BACKGROUND: Studies have demonstrated that immunity against platelet (PLT) transfusions is dependent on recipient antigen‐presenting cells (APCs) and their ability to produce nitric oxide (NO). To further analyze this, we focused on NO's major metabolite peroxynitrite (ONOO‐) and its ability to affect PLT immunity. STUDY DESIGN AND METHODS: To address how NO and its major metabolite may mediate PLT immunity, GP91PHOX knockout (KO) mice that lack the ability to produce the ONOO‐ were transfused weekly with allogeneic BALB/c PLTs, and donor antibody development was analyzed. RESULTS: Compared with controls, GP91PHOX KO mice developed significantly (p
ISSN:	0041-1132 1537-2995
DOI:	10.1111/j.1537-2995.2008.01793.x